Here is the sequence logo predicted by the SAM server:
H = helix
E = sheet
C = loop (or coil)
The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.
For example, the Glutamates at residues 27 & 28 are predicted to be in a helix. However, the Glutamates at residues 159 & 161 are predicted to be part of a sheet!
The above predictions are already on the starting model (based on the horizontal lines in the above figure).
If you are a new Foldit player, please make sure you have completed all these tutorials before trying this puzzle:
- lonely sheets,
- lock and lower,
- structure and rebuild,
- control over clashing.
For such a large puzzle it would seem we would have longer to work on it. Maybe 6 day.
When Puzzle 823 closes, we'll post a follow-up puzzle for this CASP ROLL target with server predictions. We can extend the deadline for the follow-up puzzle if you would like.