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823: Large CASP ROLL Target R0044
Status: Closed

Summary

Name: 823: Large CASP ROLL Target R0044
Status: Closed
Created: 12/14/2013
Points: 100
Expired: 12/22/2013 - 08:00
Difficulty: Intermediate
Description: This unsolved CASP ROLL target is larger than most Foldit puzzles, at 204 residues. There are no homologs, so we are starting you from an extended chain. After this puzzle closes, there will be one more round with server predictions. See the puzzle comments for secondary structure predictions.
Categories: CASP ROLL, Overall, Prediction

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Comments

bkoep's picture
User offline. Last seen 3 hours 21 min ago. Offline
Joined: 11/15/2012
Groups: None
Here are the secondary structure predictions!

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Glutamates at residues 27 & 28 are predicted to be in a helix. However, the Glutamates at residues 159 & 161 are predicted to be part of a sheet!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).

________________

If you are a new Foldit player, please make sure you have completed all these tutorials before trying this puzzle:
- lonely sheets,
- lock and lower,
- rebuild,
- structure and rebuild,
- control over clashing.

Joined: 02/08/2012
Groups: None
More Time

For such a large puzzle it would seem we would have longer to work on it. Maybe 6 day.

bkoep's picture
User offline. Last seen 3 hours 21 min ago. Offline
Joined: 11/15/2012
Groups: None
Extended round 2

When Puzzle 823 closes, we'll post a follow-up puzzle for this CASP ROLL target with server predictions. We can extend the deadline for the follow-up puzzle if you would like.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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