Fri, 11/29/2013 - 20:43
#2
Overwhelmed by possibilities
This is a pretty fascinating puzzle. It wasn't long before I had a fairly natural looking fold that ALSO had a tight symmetric cluster of 4 cysteines and 2 histidines. I'm not sure how to distribute my bridges, or how many bridges I should have. As my score increased, things started to wander apart. Any suggestions for how the active site should look?
If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864
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If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit:
- try all puzzles not only "beginner" ones,
- fold first the ones you like the most,
- try by yourself to understand what works and what doesn't,
- ask for tips in global when you think you doesn't understand something.
Make sure you have followed these tutorials:
- lonely sheets,
- lock and lower,
- rebuild,
- structure and rebuild,
- control over clashing
before starting this puzzle.
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Original Puzzle:
http://fold.it/portal/node/451446