puzzle picture
811: Abeta Binder Redesign: Round 2
Status: Closed

Summary

Name: 811: Abeta Binder Redesign: Round 2
Status: Closed
Created: 11/19/2013
Points: 100
Expired: 11/26/2013 - 23:00
Difficulty: Intermediate
Description: This is a follow-up puzzle to Puzzle 801b. We chose nine of the most promising solutions from that puzzle and added an extra beta-strand to each subunit of the Abeta binder—reset this puzzle to cycle through these nine starting structures. Like in Puzzle 801b, the Abeta protein backbone is frozen, and now you can mutate all residues in the binder subunits. Each chain has a separate RMSD condition, so only slight backbone movements will be tolerated, although you will be able to move the extra beta strand freely. This puzzle also includes a Residue IE filter, which monitors that all PHY, TYR, and TRP residues are scoring well. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions. See the new blog entry about this puzzle for more information and a picture of the sort of backbone configuration that we're aiming for.
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Anthropic Dreams11,000100
2L'Alliance Francophone10,97785
3Gargleblasters10,93572
4Contenders10,91361
5 An Art That's Smart10,90451

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons