puzzle picture
805: Ferredoxin Pentamer Design
Status: Closed

Summary

Name: 805: Ferredoxin Pentamer Design
Status: Closed
Created: 11/05/2013
Points: 100
Expired: 11/13/2013 - 01:00
Difficulty: Intermediate
Description: In this puzzle you can redesign a protein that was originally designed in the Baker Lab. This ferredoxin-like fold is very stable as a monomer, and the Baker Lab is trying to redesign it to form a symmetric pentamer. The backbone is locked for most of the protein, but you can mutate surface residues to improve the pentamer interface. You can also design a 10 residue extension at the N- or C-terminus to improve the binding interface between monomer units; reset the puzzle to alternate between the extended N- and C-terminus versions. This puzzle also includes a Residue IE filter, which monitors that all PHE, TYR, and TRP residues are scoring well.
Categories: Design, Overall, Symmetry

Top Groups

RankGroupScorePoints
1L'Alliance Francophone13,057100
2Contenders13,00883
3Anthropic Dreams12,92769
4Team Hungary12,89956
5Beta Folders12,89645

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons