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805: Ferredoxin Pentamer Design
Status: Closed
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Summary
| Name: | 805: Ferredoxin Pentamer Design |
|---|---|
| Status: | Closed |
| Created: | 11/05/2013 |
| Points: | 100 |
| Expired: | 11/13/2013 - 01:00 |
| Difficulty: | Intermediate |
| Description: | In this puzzle you can redesign a protein that was originally designed in the Baker Lab. This ferredoxin-like fold is very stable as a monomer, and the Baker Lab is trying to redesign it to form a symmetric pentamer. The backbone is locked for most of the protein, but you can mutate surface residues to improve the pentamer interface. You can also design a 10 residue extension at the N- or C-terminus to improve the binding interface between monomer units; reset the puzzle to alternate between the extended N- and C-terminus versions. This puzzle also includes a Residue IE filter, which monitors that all PHE, TYR, and TRP residues are scoring well. |
| Categories: | Design, Overall, Symmetry |
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