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802: Revisiting Puzzle 686: Black Belt De-novo
Status: Closed

Summary

Name: 802: Revisiting Puzzle 686: Black Belt De-novo
Status: Closed
Created: 10/30/2013
Points: 100
Expired: 11/04/2013 - 23:00
Difficulty: Intermediate
Description: This is a repost of Puzzle 686. When this puzzle ran in March of this year, the structure of this protein was still unknown. Now the structure has been published, and we're making the puzzle available for the Black Belt Folding broadcast this weekend! This puzzle will be used during the Black Belt Folding session, so take some time to familiarize yourself with the puzzle ahead of time. Players will NOT be able to load in any previous solutions for these puzzles.
Categories: Overall, Prediction

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Comments

bkoep's picture
User offline. Last seen 12 hours 17 min ago. Offline
Joined: 11/15/2012
Groups: None
Here are the secondary structure predictions!

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 25 & 58 are highly predicted to be part of a sheet. However, the Alanines at residues 40 & 47 are predicted to be in a helix!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).

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If you are a new Foldit player, please make sure you have completed all these tutorials before trying this puzzle:
- lonely sheets,
- lock and lower,
- rebuild,
- structure and rebuild,
- control over clashing.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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