Mutate loves arginine on 801

Case number:699969-996185
Topic:General
Opened by:Susume
Status:Closed
Type:Suggestion
Opened on:Tuesday, October 29, 2013 - 03:05
Last modified:Sunday, November 3, 2013 - 22:59

For some reason mutate has a very strong preference for arginine on 801. It gave me 36 args in the mutable area; I changed half to lysine and fused, then ran mutate again, and it promptly changed them all back. For comparison, it gave me only 1 asp and 4 glu. Not a normal looking protein.

(Tue, 10/29/2013 - 03:05  |  3 comments)


wisky's picture
User offline. Last seen 2 weeks 2 days ago. Offline
Joined: 07/13/2011

I added a comment about this in the puzzle comments. Does seem wrong.... just too many arginines :(

Joined: 12/06/2008
Groups: Contenders

Mutate also penalizes the aromatic side chains too heavily. Mass mutate will not allow a single phenylalanine, tyrosine, or tryptophan in the protein, even if there's a void large enough to easily hold one of these.

Perhaps it's again time to modify the scoring algorithms?

Joined: 12/06/2008
Groups: Contenders
Status: Open » Closed

Puzzle 801 closed and replaced with 801b, which doesn't favor arginine so highly. (Although it still discriminates against aromatics.)

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