puzzle picture
801: Abeta Binder Redesign
Status: Closed


Name: 801: Abeta Binder Redesign
Status: Closed
Created: 10/28/2013
Points: 0
Expired: 11/04/2013 - 23:00
Difficulty: Intermediate
Description: In this puzzle, you can redesign a protein that was found to bind Abeta, a peptide associated with Alzheimer's disease. See the blog post about this for more information. The Abeta protein backbone is frozen in this puzzle. The binding protein consists of two chains, in which you can mutate all but several loop residues. Each chain has a separate RMSD condition, so only slight backbone movements will be tolerated. This puzzle also includes a Residue IE filter, which monitors that all PHY, TYR, and TRP residues are scoring well. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions. Help us design a tighter-binding protein for Abeta!

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Joined: 06/24/2008
Groups: Void Crushers
Dumb Question

The two different Exploration multiples are for the two different parts? Just making sure I understand what is there.

bkoep's picture
User offline. Last seen 12 hours 48 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

The starting model of the binding protein is a dimer of two nearly-identical chains. There is an RMSD filter for each chain of the binding protein.

I apologize that we could not label each filter for its corresponding chain.

wisky's picture
User offline. Last seen 1 year 35 weeks ago. Offline
Joined: 07/13/2011

Seems the only way to get a decent score on this puzzle is to place arginines all across the outside of the helices. Something just seems off about it.

bkoep's picture
User offline. Last seen 12 hours 48 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Puzzle reposted

Thanks for commenting about this. There was a problem with the score function in this puzzle, so it has been closed and reposted as Puzzle 801b.

The reposted puzzle can be found here:

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons