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783: 60 Residue Symmetric Dimer with a Disulfide
Status: Closed


Name: 783: 60 Residue Symmetric Dimer with a Disulfide
Status: Closed
Created: 09/23/2013
Points: 100
Expired: 10/01/2013 - 19:00
Difficulty: Intermediate
Description: This is a 60 residue symmetric dimer design puzzle; there will be two symmetric chains to manage. This puzzle also contains a disulfide filter: you will receive a bonus for making one disulfide bond between the two subunits, but there is no bonus for a disulfide bond between two residues of the same subunit. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. See the blog post about this for more information. In addition to the disulfide filter, there are two other filters enabled on this puzzle: the Residue IE Score monitors that all PHY, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions.
Categories: Design, Overall, Symmetry

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brow42's picture
User offline. Last seen 1 year 36 weeks ago. Offline
Joined: 09/19/2011
Groups: None
Unable to load/upload solutions

The client has a serious error that causes the loss of all work on this puzzle. Hopefully you can fix it before it closes.


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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons