puzzle picture
778: 58 Residue D2 Tetramer Design
Status: Closed


Name: 778: 58 Residue D2 Tetramer Design
Status: Closed
Created: 09/12/2013
Points: 100
Expired: 09/19/2013 - 23:00
Difficulty: Intermediate
Description: This is a 58 residue tetramer design puzzle with D2 symmetry; there will be four symmetric chains to manage. Note that the score of a symmetric protein relies not only on how well-folded each chain is, but also on how well the chains interface together. See the blog post about this for more information. There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHY, TYR, and TRP residues are scoring well, and the Core Exists filter checks that at least 30% of the residues are buried in the core of your design. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions.
Categories: Design, Overall, Symmetry

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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