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767: De-novo Freestyle 28: Hand-folding Round
Status: Closed

Summary

Name: 767: De-novo Freestyle 28: Hand-folding Round
Status: Closed
Created: 08/22/2013
Points: 100
Expired: 08/30/2013 - 08:00
Difficulty: Intermediate
Description: We are giving you another currently unsolved protein as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.
Categories: Hand-Folding, Overall, Prediction

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Comments

bkoep's picture
User offline. Last seen 3 hours 37 min ago. Offline
Joined: 11/15/2012
Groups: None
Here are the secondary structure predictions!

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 84-87 is highly predicted to be part of a sheet. However, the Valines at residues 117 & 121 are predicted to be in a helix!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).

________________

If you are a new Foldit player, please make sure you have completed all these tutorials before trying this puzzle:
- lonely sheets,
- lock and lower,
- rebuild,
- structure and rebuild,
- control over clashing.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons