puzzle picture
753: 91 Residue Dimer Design
Status: Closed

Summary

Name: 753: 91 Residue Dimer Design
Status: Closed
Created: 07/26/2013
Points: 100
Expired: 08/05/2013 - 12:00
Difficulty: Intermediate
Description: This is a 91 residue symmetric dimer design puzzle; there will be two symmetric chains to manage. Note that the score of a symmetric protein relies not only on how well-folded each chain is, but also on how well the chains interface together. See the blog post about this for more information. There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHY, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions.
Categories: Design, Overall, Symmetry

Top Groups

RankGroupScorePoints
1Contenders14,774100
2Void Crushers14,70382
3Anthropic Dreams14,42566
4Team Hungary14,28953
5Go Science14,27042

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons