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731: Unsolved Chicken Anemia Virus Protein (CLOSED and reposted as 731b)
Status: Closed

Summary

Name: 731: Unsolved Chicken Anemia Virus Protein (CLOSED and reposted as 731b)
Status: Closed
Created: 06/15/2013
Points: 0
Expired: 06/25/2013 - 22:00
Difficulty: Intermediate
Description: Apoptin is a viral protein of special interest because it targets cancer cells and causes apoptosis. Solving this protein structure would greatly advance research into apoptin’s functionality and development as a method to treat cancer. Resetting the puzzle will cycle through 5 Zhang server predictions that are also in the Alignment Tool so you can use partial threading. So that you have plenty of time to try out each model, this puzzle will be up for 10 days and worth 150 global points! More info in the puzzle comments.
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Comments

beta_helix's picture
User offline. Last seen 4 hours 25 min ago. Offline
Joined: 05/09/2008
Groups: None
More info:

Here are the secondary structure predictions predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Threonines at residues 41 and 43 are highly predicted to be part of a sheet. However, the Threonines at residues 68 and 114 are not predicted to be anything!
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More details in the blogpost for this puzzle: http://fold.it/portal/node/995344

Joined: 12/02/2008
Groups: Void Crushers
cys bonding

is cys bonding being given extra points?

beta_helix's picture
User offline. Last seen 4 hours 25 min ago. Offline
Joined: 05/09/2008
Groups: None
Great question!

Thanks for bringing this up, MikeCassidy!
(I'm glad to see that my last sentence in this blogpost worked so fast :-)

We did NOT turn on the Disulfide Count Score Filter on this puzzle, but it can easily be added if needed.

I have asked the scientists at the Worcester Polytechnic Institute who are working on this unsolved protein for their expertise on the matter.

Thank you again for asking this!

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons