725: Quick 60 Residue Tetramer Redesign
|Name:||725: Quick 60 Residue Tetramer Redesign|
|Expired:||06/09/2013 - 02:00|
|Description:||This is a 60 residue symmetric tetramer design puzzle. The starting structure is a solution to Puzzle 691 that was shared with us by MurloW. The scientists at the Baker Lab like the topology of this solution, but simulations predict that this amino acid sequence will not fold up properly from an extended chain. Help us redesign this solution into a folding protein! The ResidueIE and "Core Exists" filters will make sure PHY, TYR, and TRP residues are scoring well, and that the protein core includes at least 35% of the residues. We look forward to seeing your mutations to this fold, although you are free to redesign the entire protein in this puzzle.|
|Categories:||Design, Overall, Symmetry|
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