puzzle picture
725: Quick 60 Residue Tetramer Redesign
Status: Closed

Summary

Name: 725: Quick 60 Residue Tetramer Redesign
Status: Closed
Created: 06/04/2013
Points: 100
Expired: 06/09/2013 - 02:00
Difficulty: Intermediate
Description: This is a 60 residue symmetric tetramer design puzzle. The starting structure is a solution to Puzzle 691 that was shared with us by MurloW. The scientists at the Baker Lab like the topology of this solution, but simulations predict that this amino acid sequence will not fold up properly from an extended chain. Help us redesign this solution into a folding protein! The ResidueIE and "Core Exists" filters will make sure PHY, TYR, and TRP residues are scoring well, and that the protein core includes at least 35% of the residues. We look forward to seeing your mutations to this fold, although you are free to redesign the entire protein in this puzzle.
Categories: Design, Overall, Symmetry

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Comments

Joined: 12/06/2008
Groups: Contenders
No wiggle.

Wiggle doesn't work, even with the "Disable Slow Filters" box checked and the CI pulled way down. Neither does Shake. Mutate barely works.

If anyone else is experiencing this, I'll file a trouble ticket.

Joined: 02/08/2012
Groups: None
I agree

there are some problems with wiggle. shake seems to be slow. however, wiggling sidechains seems to work the best. If there are a lot of bands, wiggle backbone does work a little bit; but still, not very well. if you select sheets and helices one by one, mutate works fairly fast.

Joined: 09/24/2012
Groups: Go Science
no

Everything is ok for me. May be restart all clients ?

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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