puzzle picture
720: Quick Puzzle: 76 Residue Dimer
Status: Closed

Summary

Name: 720: Quick Puzzle: 76 Residue Dimer
Status: Closed
Created: 05/28/2013
Points: 100
Expired: 05/31/2013 - 23:59
Difficulty: Intermediate
Description: This is 76 residue symmetric dimer design puzzle, much like Puzzle 708. There are two flters enabled on this puzzle. The ResidueIE filter ensures PHY, TYR, and TRP residues are scoring well. The "Core Exists" filter ensures the number of residues in the core is at least 30%. We're starting you with johnmitch's monomer solution to Puzzle 687, but we've mutated all residues to isoleucine. You'll have to make your own mutations and design a well-packed dimer interface to increase your score. This is just a starting point, of course; you are free to redesign the entire protein in this puzzle.
Categories: Design, Overall, Symmetry

Top Groups

RankGroupScorePoints
1Anthropic Dreams12,921100
2Void Crushers12,87580
3Clear the Way12,82663
4SETI.Germany12,81949
5L'Alliance Francophone12,81437

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons