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720: Quick Puzzle: 76 Residue Dimer
Status: Closed


Name: 720: Quick Puzzle: 76 Residue Dimer
Status: Closed
Created: 05/28/2013
Points: 100
Expired: 05/31/2013 - 23:59
Difficulty: Intermediate
Description: This is 76 residue symmetric dimer design puzzle, much like Puzzle 708. There are two flters enabled on this puzzle. The ResidueIE filter ensures PHY, TYR, and TRP residues are scoring well. The "Core Exists" filter ensures the number of residues in the core is at least 30%. We're starting you with johnmitch's monomer solution to Puzzle 687, but we've mutated all residues to isoleucine. You'll have to make your own mutations and design a well-packed dimer interface to increase your score. This is just a starting point, of course; you are free to redesign the entire protein in this puzzle.
Categories: Design, Overall, Symmetry

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons