puzzle picture
708: Multi-Start 76 Residue Symmetric Dimer
Status: Closed

Soloists

RankPlayerGroupScorePoints
226Kipnation 149 13788  11,5591
227dagg83 149 13788  11,5571
228hkilik 149 13788  11,5541
229Femto 149 13788  11,5481
230lacie 149 13788  11,5371
231Swiftcristal 149 13788  11,5321
232Agni23 149 13788  11,5291
233Red John 149 13788  11,5221
234tvsmash 149 13788  11,5181
235fab.brito 149 13788  11,5151
236maciej1234567 149 13788  11,5021
237kgofz9 149 13788  11,5001
238Robcot 149 13788  11,4951
239Goldn654 149 13788  11,4761
240migst 149 13788  11,4601
241iqbalmahmud 149 13788  11,4301
242DarkShadow44 149 13788  11,4251
243bsdgc 149 13788  11,4171
244Wesley_M_Price 149 13788  11,4111
245JamesLeCornu 149 13788  11,3811
246greepski 149 13788 Gargleblasters11,3621
247ku3mi41 149 13788 Russian team11,2951
248rawkus 149 13788  11,2781
249Hematite12 149 13788 Go Science11,2721
250drrocco 149 13788  11,2681


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Comments

Joined: 05/11/2012
More Info

We are continuing to work on getting rid of the filters, but at this time we still need to enable the "Core Exists" and "ResidueIE" filters. We are working with the scientists in the Bakerlab to come up with new ways to achieve the same results without the filters, but we ask for you to bear with us until that happens.

These filters are nowhere as slow as the 'Layer Design' filter, so hopefully they do not hinder your puzzle progress and enjoyment of design.

One reason we were able to remove the 'Layer Design' filter is because we are now using a score term called 'envsmooth'. What this term does is look at the environment around each amino acid and determine if it is statistically similar to the environment found in similar amino acids in native proteins. In earlier design puzzles, this score term was not used. Initially when we used this score term players were able to get high scoring crazy solutions in devprev. We have modified it so that should no longer be possible.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons