tamirh's picture
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Joined: 05/11/2012
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We are continuing to work on getting rid of the filters, but at this time we still need to enable the "Core Exists" and "ResidueIE" filters. We are working with the scientists in the Bakerlab to come up with new ways to achieve the same results without the filters, but we ask for you to bear with us until that happens.

These filters are nowhere as slow as the 'Layer Design' filter, so hopefully they do not hinder your puzzle progress and enjoyment of design.

One reason we were able to remove the 'Layer Design' filter is because we are now using a score term called 'envsmooth'. What this term does is look at the environment around each amino acid and determine if it is statistically similar to the environment found in similar amino acids in native proteins. In earlier design puzzles, this score term was not used. Initially when we used this score term players were able to get high scoring crazy solutions in devprev. We have modified it so that should no longer be possible.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons