puzzle picture
697: Second Hand-Folding Sepsis Puzzle
Status: Closed

Summary

Name: 697: Second Hand-Folding Sepsis Puzzle
Status: Closed
Created: 04/05/2013
Points: 100
Expired: 04/18/2013 - 12:00
Difficulty: Intermediate
Description: Sugar molecules such as the one here are coated on the surface of many human pathogens. We are attempting to increase the protein-sugar binding interactions by allowing you to redesign & insert up to 6 residues to form additional hydrogen bonds with the sugar. To encourage this, only GUI scripts are allowed, and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You will be able to load in your solutions from the first puzzle and refine them with scripting and sharing. Please read the new puzzle comments for more details. AND PLEASE NOTICE that Valine 32 can be mutated!
Categories: Design, Hand-Folding, Overall

Top Groups

RankGroupScorePoints
1Anthropic Dreams9,658100
2Beta Folders9,48786
3Gargleblasters9,44973
4Contenders9,34362
5foldeRNA9,24752

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beta_helix's picture
User offline. Last seen 12 hours 47 min ago. Offline
Joined: 05/09/2008
Groups: None
Additional info about this puzzle:

Please read the new Blog Entry about this puzzle: http://fold.it/portal/node/994592

PLEASE NOTE that Valine 32 can be mutated!
___________________________________________

If you are new to Foldit, make sure you have completed Intro Puzzles 7-1 through 7-4 before trying this puzzle.
___________________________________________

This puzzle has the ResidueIE filter on (to try to ensure that PHE, TYR, and TRP residues are scoring properly) and we've increased the Ligand Score by a factor of 10 to promote interactions with the sugar.

Tip: To see the parts of the sugar that you can bond to, check Show bonds (non-protein) and Show bondable atoms in the View menu. Make sure Show bonds (loop) and Show bonds (sidechain) are also on. Blue can bond to red, and purple can bond to either blue or red.

beta_helix's picture
User offline. Last seen 12 hours 47 min ago. Offline
Joined: 05/09/2008
Groups: None
There will be a Scientist Chat about this puzzle

this coming Tuesday April 9th at 2pm PT.

More details will be posted in the news.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons