695: 70 Residue Trimer [deprecated]

Summary

Name:

Status:

Closed

Created:

04/01/2013

Points:

Expired:

04/10/2013 - 20:00

Difficulty:

Intermediate

Description:

This is a 70 residue symmetric trimer design puzzle; there will be three symmetric chains to manage. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. See the blogpost about this: http://fold.it/portal/node/993871 There is only 1 filter enabled in this puzzle. The Residue IE Score monitors all PHY, TYR, and TRP residues are scoring well. Press TAB on each residue to find out exactly what it expects of residues that do not meet the IE (interaction energy) requirements. The score function is slightly different than on previous symmetry puzzles. We're hoping to see if this modification can replace the slow filters that have been previously enabled in other puzzles.

Categories:

Rank

Group

Score

Points

37,687

36,604

36,534

36,327

35,572

Rank

Player

Group

Score

Points

cassandraberry81897 75 1437

36,500

36,500

35,941

35,938

35,554

Rank

Player

Group

Score

Points

37,687

36,629

36,604

36,534

36,327

Tue, 04/02/2013 - 19:41

steveB 75 1437

Offline

Joined: 01/08/2009

Groups: Void Crushers

Is this puzzle is broken ??

This puzzle gives a higher score the further away the three copies are from each other, with all hydrophilic side chains.

Tue, 04/02/2013 - 20:14

beta_helix 75 645

Offline

Joined: 05/09/2008

Groups: None

Sadly, it appears that this puzzle is not behaving itself!

Hopefully you saw David Baker's blog entry from this morning where he pointed out that we are trying to solve the slow filters issue (that generate great results but make gameplay impossible) by trying to change parameters in the score function (to get rid of most filters, while preserving your great results).

Unfortunately, it's evident that the top-scoring results that are being generated with this new puzzle are far from great... but hopefully the speed issue for this puzzle seems to be working ok.

So yes... this puzzle is broken and will likely be closed very soon.

We apologize for this, and will probably post it in devprev so that we can sort out these issues before posting it as a regular puzzle.

Thanks again for your patience and especially for pointing out how broken this puzzle is!
For example, check out the images here: http://fold.it/portal/node/994872

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