puzzle picture
695: 70 Residue Trimer [deprecated]
Status: Closed


Name: 695: 70 Residue Trimer [deprecated]
Status: Closed
Created: 04/01/2013
Points: 0
Expired: 04/10/2013 - 20:00
Difficulty: Intermediate
Description: This is a 70 residue symmetric trimer design puzzle; there will be three symmetric chains to manage. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. See the blogpost about this: http://fold.it/portal/node/993871 There is only 1 filter enabled in this puzzle. The Residue IE Score monitors all PHY, TYR, and TRP residues are scoring well. Press TAB on each residue to find out exactly what it expects of residues that do not meet the IE (interaction energy) requirements. The score function is slightly different than on previous symmetry puzzles. We're hoping to see if this modification can replace the slow filters that have been previously enabled in other puzzles.

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steveB's picture
User offline. Last seen 2 years 4 weeks ago. Offline
Joined: 01/08/2009
Groups: Void Crushers
Is this puzzle is broken ??

This puzzle gives a higher score the further away the three copies are from each other, with all hydrophilic side chains.

beta_helix's picture
User offline. Last seen 5 hours 55 min ago. Offline
Joined: 05/09/2008
Groups: None
Sadly, it appears that this puzzle is not behaving itself!

Hopefully you saw David Baker's blog entry from this morning where he pointed out that we are trying to solve the slow filters issue (that generate great results but make gameplay impossible) by trying to change parameters in the score function (to get rid of most filters, while preserving your great results).

Unfortunately, it's evident that the top-scoring results that are being generated with this new puzzle are far from great... but hopefully the speed issue for this puzzle seems to be working ok.

So yes... this puzzle is broken and will likely be closed very soon.

We apologize for this, and will probably post it in devprev so that we can sort out these issues before posting it as a regular puzzle.

Thanks again for your patience and especially for pointing out how broken this puzzle is!
For example, check out the images here: http://fold.it/portal/node/994872

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons