Can we have a metal to bind to? (693)
|Opened on:||Sunday, March 31, 2013 - 06:50|
|Last modified:||Tuesday, April 9, 2013 - 05:47|
When you release the open phase of 693 denovo #22, would it be possible to give us an iron-sulfur cluster to bind the cystines to? They seem to be extremely well conserved in homologs but are too close together for a disulfide between them to make much sense - I'm thinking they are likely part of the active site. We could more likely get that part of the backbone right if we had the right sort of thing to bind to. People who don't want to mess with the metal could drag it away from the protein and forget it.