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691: 60 Residue Tetramer
Status: Closed


Name: 691: 60 Residue Tetramer
Status: Closed
Created: 03/21/2013
Points: 100
Expired: 04/08/2013 - 19:00
Difficulty: Advanced
Description: This is a 60 residue symmetric tetramer design puzzle; there will be four symmetric chains to manage. This particular type of symmetry is a ring (C4) symmetry. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. See the blogpost about this: http://fold.it/portal/node/993871 There are 4 filters enabled in this puzzle. They are slow to compute, so you may want to check "Disable slow filters" in the behavior tab for when you are manually pulling and running your scripts. You should remember to turn the filters back on though, because only then will you see your true score. The ResidueIE filter ensures PHY, TYR, and TRP residues are scoring well. The "Core Exists" filter ensures the number of residues in the core is between 30% and 70%. The "Polar Core" filter that the residues in the core are properly hydrophobic. The "Layer Design" filter looks at the interactions of the residues based on the surface area of the protein. Residues can be either in the core, on the boundary or on the surface of the protein. Depending on the surroundings, the "Layer Design" filter will give you a bonus if your amino acid matches what it was expecting based on an analysis of the surface area of the protein. Press TAB on each residue to find out more about these filters.
Categories: Design, Overall, Symmetry

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beta_helix's picture
User offline. Last seen 7 hours 59 min ago. Offline
Joined: 05/09/2008
Groups: None
This puzzle's deadline has been extended by 1 week

Due to the new filters slowing things down, and since there are many design puzzles up, we've extended this deadline by 1 week.

brow42's picture
User offline. Last seen 1 year 36 weeks ago. Offline
Joined: 09/19/2011
Groups: None
GUI Mutate behavior

FYI: I ran mutate for 8 hours with filters on, and at the end, I have "Too many polar residues in the core" and 19 invalid residues. (monomer is all helices).

Joined: 12/06/2008
Groups: Contenders
The big ol' helix wins... again... and again.

Just want to report to the devs that once again, even with the filters, a megahelix scores far higher than any realistic structure.

tamirh's picture
User offline. Last seen 8 years 31 weeks ago. Offline
Joined: 05/11/2012
For those that missed the scientist chat

You can find it here: http://fold.it/portal/node/994899

A summary about this issue is that in symmetry these helices are boring, but they're stable. So it's not super surprising that they score well.

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