puzzle picture
690: 76 Residue Dimer
Status: Closed

Summary

Name: 690: 76 Residue Dimer
Status: Closed
Created: 03/20/2013
Points: 100
Expired: 04/04/2013 - 01:00
Difficulty: Advanced
Description: This is a 76 residue symmetric dimer design puzzle. You will be able to load in your monomer solutions from "687: 76 Residue Monomer Repost". A symmetric protein relies not only on how well folded each part is, but also on how well they interface together; see the latest blogpost about this: http://fold.it/portal/node/993871 There are 4 filters enabled in this puzzle. They are slow to compute, so you may want to check "Disable slow filters" in the behavior tab for when you are manually pulling and running your scripts. The ResidueIE filter ensures PHY, TYR, and TRP residues are scoring well. The "Core Exists" filter ensures the number of residues in the core is between 30% and 70%. The "Polar Core" filter that the residues in the core are properly hydrophobic. The "Layer Design" filter looks at the interactions of the residues based on the surface area of the protein. Residues can be either in the core, on the boundary or on the surface of the protein. Depending on the surroundings, the "Layer Design" filter will give you a bonus if your amino acid matches what it was expecting. Press TAB on each residue to find out more about these filters.
Categories: Design, Overall, Symmetry

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RankGroupScorePoints
1Void Crushers13,749100
2Another Hour Another Point13,66283
3Anthropic Dreams13,62869
4Gargleblasters13,61856
5Beta Folders13,28845

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Comments

beta_helix's picture
User offline. Last seen 6 days 11 hours ago. Offline
Joined: 05/09/2008
Groups: None
This puzzle's deadline has been extended by 1 week

Due to the new filters slowing things down, and since there are many design puzzles up, we've extended this deadline by 1 week.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons