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689: (Old) Hand-Folding CASP10 T0711 Repost
Status: Closed

Summary

Name: 689: (Old) Hand-Folding CASP10 T0711 Repost
Status: Closed
Created: 03/19/2013
Points: 0
Expired: 03/27/2013 - 22:00
Difficulty: Intermediate
Description: This puzzle has been reposted. Please use the new version of this puzzle, 689b. You may load your MANUAL saves into the new puzzle. We apologize for any inconvenience.
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beta_helix's picture
User offline. Last seen 3 hours 32 min ago. Offline
Joined: 05/09/2008
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Additional info about this puzzle:

This puzzle uses the new Disulfide Count Score Filter to address some of the problems pointed out by players when this puzzle was posted during CASP10:
http://fold.it/portal/node/992993#comment-18429
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Here is the CASP link for this target (showing the amino acid sequence):
http://predictioncenter.org/casp10/target.cgi?id=120
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Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

You can see that these secondary structure predictions imply that this protein is mostly loop!
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Link to template PDBs:

http://www.pdb.org/pdb/explore/explore.do?structureId=1lu0
http://www.pdb.org/pdb/explore/explore.do?structureId=1w7z
http://www.pdb.org/pdb/explore/explore.do?structureId=1h9h

____________________________________________________

For those of you who miss your scripts, don't worry: the "normal" version of this puzzle will be reposted next week (allowing you to you to load in your manual saves from this puzzle).

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons