puzzle picture
686: De-novo Freestyle 21
Status: Closed


Name: 686: De-novo Freestyle 21
Status: Closed
Created: 03/12/2013
Points: 100
Expired: 03/22/2013 - 13:00
Difficulty: Intermediate
Description: This currently unsolved short protein does not have any templates that we can use, so we are giving it to you as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.
Categories: Overall, Prediction

Top Groups

41null pointer exception7,1961
42Cedarburg H.S.7,1361
43DSN @ Home7,0771
45Window Group7,0751

Top Evolvers

Top Soloists

41utaca 70 1837 Void Crushers9,80355
42Lecc 70 1837 Russian team9,78454
43BootsMcGraw 14 10 Contenders9,78253
44eikem 70 1837  9,78152
45brow42 70 1837  9,78151

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beta_helix's picture
User offline. Last seen 1 day 15 hours ago. Offline
Joined: 05/09/2008
Groups: None
Here are the secondary structure predictions!

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 25 & 58 are highly predicted to be part of a sheet. However, the Alanines at residues 40 & 47 are predicted to be in a helix!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).

marie_s's picture
User offline. Last seen 1 year 15 weeks ago. Offline
Joined: 05/18/2008
Groups: None
this puzzle is not difficult

It is easiest that many new ones with layers.
Please put this type of puzzle in intermediate, I think new ones may have fun plying with them.

For new ones, just check you have do all these tutorials:
- lonely sheets,
- lock and lower,
- rebuild,
- structure and rebuild,
- control over clashing.

beta_helix's picture
User offline. Last seen 1 day 15 hours ago. Offline
Joined: 05/09/2008
Groups: None
Thanks marie_s

I have switched it to "Intermediate" and we'll make the Design puzzles with Filters "Advanced" from now on (until we are able to make them easier!)

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