puzzle picture
686: De-novo Freestyle 21
Status: Closed

Soloists

RankPlayerGroupScorePoints
276richard c 70 1811  8,0501
277j_pip 70 1811  8,0361
278bc09 70 1811  8,0091
279Steidemeister56 70 1811  7,9751
280DMStheWriter 70 1811  7,9391
281Ossiito 70 1811  7,9071
282pstaff2 70 1811  7,9011
283lassehornbek 70 1811  7,8981
284thomas820605 70 1811  7,8601
285Susanne 70 1811 SETI.Germany7,8181
286SHK5P 70 372  7,7861
287rol 70 1811  7,7621
288ZeroLeak7 49 63 7Monkeys7,7071
289dingdinglhz 70 1811  7,6271
290mind_hack 70 1811  7,5871
291plh 70 1811 Friday Lab7,5691
292bkaplan1998 70 1811  7,5671
293Thooliv 70 1811  7,5191
294George15 70 1811  7,5091
295alanrichard 70 1811  7,5081
296squidmaster 70 1811  7,3741
297coolbr 70 1811  7,3371
298nickbobbitt2015 70 1811  7,2941
299hbond31 70 1811  7,2041
300tamirh 70 1811 null pointer exception7,1961


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Comments

beta_helix's picture
User offline. Last seen 13 hours 27 min ago. Offline
Joined: 05/09/2008
Groups: None
Here are the secondary structure predictions!

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 25 & 58 are highly predicted to be part of a sheet. However, the Alanines at residues 40 & 47 are predicted to be in a helix!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).

marie_s's picture
User offline. Last seen 1 year 15 weeks ago. Offline
Joined: 05/18/2008
Groups: None
this puzzle is not difficult

It is easiest that many new ones with layers.
Please put this type of puzzle in intermediate, I think new ones may have fun plying with them.

For new ones, just check you have do all these tutorials:
- lonely sheets,
- lock and lower,
- rebuild,
- structure and rebuild,
- control over clashing.

beta_helix's picture
User offline. Last seen 13 hours 27 min ago. Offline
Joined: 05/09/2008
Groups: None
Thanks marie_s

I have switched it to "Intermediate" and we'll make the Design puzzles with Filters "Advanced" from now on (until we are able to make them easier!)

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons