puzzle picture
686: De-novo Freestyle 21
Status: Closed

Soloists

RankPlayerGroupScorePoints
276richard c 80 1347  8,0501
277j_pip 80 1347  8,0361
278bc09 80 1347  8,0091
279Steidemeister56 80 1347  7,9751
280DMStheWriter 80 1347  7,9391
281Ossiito 80 1347  7,9071
282pstaff2 80 1347  7,9011
283lassehornbek 80 1347  7,8981
284thomas820605 80 1347  7,8601
285Susanne 80 1347 SETI.Germany7,8181
286SHK5P 80 1347  7,7861
287rol 80 550  7,7621
288ZeroLeak7 41 34 7Monkeys7,7071
289dingdinglhz 80 1347  7,6271
290mind_hack 80 1347  7,5871
291plh 80 1347 Friday Lab7,5691
292bkaplan1998 80 1347  7,5671
293Thooliv 80 1347  7,5191
294George15 80 1347  7,5091
295alanrichard 80 1347  7,5081
296squidmaster 80 1347  7,3741
297coolbr 80 1347  7,3371
298nickbobbitt2015 80 1347  7,2941
299hbond31 80 1347  7,2041
300tamirh 80 1347 null pointer exception7,1961


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Comments

beta_helix's picture
User offline. Last seen 2 days 4 hours ago. Offline
Joined: 05/09/2008
Groups: None
Here are the secondary structure predictions!

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 25 & 58 are highly predicted to be part of a sheet. However, the Alanines at residues 40 & 47 are predicted to be in a helix!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).

marie_s's picture
User offline. Last seen 1 year 49 weeks ago. Offline
Joined: 05/18/2008
Groups: None
this puzzle is not difficult

It is easiest that many new ones with layers.
Please put this type of puzzle in intermediate, I think new ones may have fun plying with them.

For new ones, just check you have do all these tutorials:
- lonely sheets,
- lock and lower,
- rebuild,
- structure and rebuild,
- control over clashing.

beta_helix's picture
User offline. Last seen 2 days 4 hours ago. Offline
Joined: 05/09/2008
Groups: None
Thanks marie_s

I have switched it to "Intermediate" and we'll make the Design puzzles with Filters "Advanced" from now on (until we are able to make them easier!)

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons