puzzle picture
686: De-novo Freestyle 21
Status: Closed

Soloists

RankPlayerGroupScorePoints
276richard c 83 1970  8,0501
277j_pip 83 1970  8,0361
278bc09 83 1970  8,0091
279Steidemeister56 83 1970  7,9751
280DMStheWriter 83 1970  7,9391
281Ossiito 83 1970  7,9071
282pstaff2 83 1970  7,9011
283lassehornbek 83 1970  7,8981
284thomas820605 83 1970  7,8601
285Susanne 83 1970 SETI.Germany7,8181
286SHK5P 83 166  7,7861
287rol 83 1970  7,7621
288ZeroLeak7 35 27 7Monkeys7,7071
289dingdinglhz 83 1970  7,6271
290mind_hack 83 1970  7,5871
291plh 83 1970 Friday Lab7,5691
292bkaplan1998 83 1970  7,5671
293Thooliv 83 1970  7,5191
294George15 83 1970  7,5091
295alanrichard 83 1970  7,5081
296squidmaster 83 1970  7,3741
297coolbr 83 1970  7,3371
298nickbobbitt2015 83 1970  7,2941
299hbond31 83 1970  7,2041
300tamirh 83 1970 null pointer exception7,1961


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Comments

beta_helix's picture
User offline. Last seen 7 hours 35 min ago. Offline
Joined: 05/09/2008
Groups: None
Here are the secondary structure predictions!

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 25 & 58 are highly predicted to be part of a sheet. However, the Alanines at residues 40 & 47 are predicted to be in a helix!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).

marie_s's picture
User offline. Last seen 1 year 4 weeks ago. Offline
Joined: 05/18/2008
Groups: None
this puzzle is not difficult

It is easiest that many new ones with layers.
Please put this type of puzzle in intermediate, I think new ones may have fun plying with them.

For new ones, just check you have do all these tutorials:
- lonely sheets,
- lock and lower,
- rebuild,
- structure and rebuild,
- control over clashing.

beta_helix's picture
User offline. Last seen 7 hours 35 min ago. Offline
Joined: 05/09/2008
Groups: None
Thanks marie_s

I have switched it to "Intermediate" and we'll make the Design puzzles with Filters "Advanced" from now on (until we are able to make them easier!)

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons