puzzle picture
686: De-novo Freestyle 21
Status: Closed

Soloists

RankPlayerGroupScorePoints
251hydrater 83 1970  8,4271
252Goldschmidt 83 1970  8,4021
253nelson1990 83 1970  8,3881
254gardenpea 83 1970 SETIKAH@KOREA8,3831
255Tac1 83 1970  8,3741
256armadillo314 83 1970  8,3661
257AVY42 83 1970  8,3621
258blochsphere 83 1970  8,3501
259madgamer2008 83 1970 Minions of TWIS8,3171
260MadisonKirkman3.14 83 1970  8,3131
261jjordan12 83 1970  8,2961
262Double-Blind 83 1970  8,2821
263multaq 83 260 L'Alliance Francophone8,2501
264construct2021 83 1970  8,2411
265One averag... 83 1970  8,2141
266Schleicher 83 675 SETI.Germany8,2111
267joremen 83 923  8,1391
268joebob5000 83 1970  8,1391
269danoran 83 1970  8,1381
270sbea3 83 1970  8,0931
271Zaeron 83 1970  8,0871
272Nuttyman02 83 1970  8,0781
273steamywindow 83 1970  8,0731
274DScott 83 193  8,0591
27521110813a 83 1970  8,0511


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Comments

beta_helix's picture
User offline. Last seen 7 hours 8 min ago. Offline
Joined: 05/09/2008
Groups: None
Here are the secondary structure predictions!

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 25 & 58 are highly predicted to be part of a sheet. However, the Alanines at residues 40 & 47 are predicted to be in a helix!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).

marie_s's picture
User offline. Last seen 1 year 4 weeks ago. Offline
Joined: 05/18/2008
Groups: None
this puzzle is not difficult

It is easiest that many new ones with layers.
Please put this type of puzzle in intermediate, I think new ones may have fun plying with them.

For new ones, just check you have do all these tutorials:
- lonely sheets,
- lock and lower,
- rebuild,
- structure and rebuild,
- control over clashing.

beta_helix's picture
User offline. Last seen 7 hours 8 min ago. Offline
Joined: 05/09/2008
Groups: None
Thanks marie_s

I have switched it to "Intermediate" and we'll make the Design puzzles with Filters "Advanced" from now on (until we are able to make them easier!)

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons