puzzle picture
679b: De-novo Freestyle 20
Status: Closed

Summary

Name: 679b: De-novo Freestyle 20
Status: Closed
Created: 02/19/2013
Points: 100
Expired: 03/01/2013 - 02:00
Difficulty: Advanced
Description: We are giving you another currently unsolved protein as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments. This is a repost of Puzzle 679, you will be able to load in your manual saves from the previous version.
Categories: Overall, Prediction

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Comments

beta_helix's picture
User offline. Last seen 6 days 17 hours ago. Offline
Joined: 05/09/2008
Groups: None
Here are the secondary structure predictions

Here is the CORRECT sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 58, 70 & 83 are predicted to be part of a sheet, but the Valine at residue 90 is not.

The above predictions are already on the starting model (based on the horizontal lines in the above figure).
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NOTE: If you did not manually save a solution in puzzle 679, you can go back to 679, manually save it, and the solution should appear in your manual saves for this puzzle.

Puzzle was reposted due to this bug: http://fold.it/portal/node/994549

beta_helix's picture
User offline. Last seen 6 days 17 hours ago. Offline
Joined: 05/09/2008
Groups: None
This puzzle's deadline has been extended

Due to the above bug (requiring this repost of the puzzle) and the fact that the other current puzzles are quite large (but the CASP ROLL puzzle deadlines cannot be extended) we have extended this puzzle's deadline.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons