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679: De-novo Freestyle 20
Status: Closed

Summary

Name: 679: De-novo Freestyle 20
Status: Closed
Created: 02/18/2013
Points: 0
Expired: 02/25/2013 - 19:00
Difficulty: Advanced
Description: This puzzle had incorrect secondary structure predictions and was replaced by 679b: http://fold.it/portal/node/994551
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Comments

beta_helix's picture
User offline. Last seen 5 hours 15 min ago. Offline
Joined: 05/09/2008
Groups: None
Here are the secondary structure predictions

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valine at residue 7 is highly predicted to be part of a helix. However, the Valines at residues 61, 73 & 86 are predicted to be part of a sheet!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).

brow42's picture
User offline. Last seen 2 years 1 week ago. Offline
Joined: 09/19/2011
Groups: None
Puzzle is truncated

The structure prediction starts with QEIPAG and ends with QIRIDKINE. However, the first 3 segments and last 4 segments have been removed from the puzzle. This means the structure prediction is off by 3. I'm sure there will be recipes posted shortly that will reapply the correct predictions. Thanks to drumpeter and frood for noticing.

beta_helix's picture
User offline. Last seen 5 hours 15 min ago. Offline
Joined: 05/09/2008
Groups: None
Nice catch

Thank you for catching this mistake!
I will repost the puzzle once the new SS predictions come back. You will be able to load in manually saves from this puzzle.

More details here: http://fold.it/portal/node/994549

Sorry for this mistake!

beta_helix's picture
User offline. Last seen 5 hours 15 min ago. Offline
Joined: 05/09/2008
Groups: None
This puzzle has now been replaced by this one:
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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