676 - with the 4 filters in place, it plays like a larger puzzle

Case number:699969-994533
Opened by:CharlieFortsCon...
Opened on:Friday, February 15, 2013 - 21:00
Last modified:Monday, February 25, 2013 - 10:44


The intention to post a dimeric version of this one - a quick question. Is the intention to have the 4 filters also active in the dimer? Or they're just here on 'version 1' of this new puzzle type?

I only ask, since in the version 1, despite it only being 76 segs long, the 4 filters are making it feel like a larger puzzle in terms of CPU. If the 4 stay in place for 'version 2', it's going to get difficult to play


(Fri, 02/15/2013 - 21:00  |  9 comments)

tamirh's picture
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Joined: 05/11/2012
Status: Open » Open

We should have a fix to this issue out soon.

Joined: 06/24/2008
Groups: Void Crushers

Wiggling does the stop&start that I thought was removed.

Joined: 08/24/2011

With a new client, PC just booted: 20minutes for a wiggle... that's three puzzles in a row I can't play. I'm getting sick of this :/

Joined: 12/06/2008
Groups: Contenders

Good thing we have ten days to work this puzzle.

I started the "Mutate Combo 1.4 for Layers" script twenty-one hours ago, and it is just now getting to the second part of the script, where it mutates individual sidechains. Granted, puzzle # 676 has over twice as many mutable residues as any other protein we've designed. But this script has run ten times as long as it should have to get to the point where it is.

It's dragging down performance on any other puzzle I try to run, simultaneously, due to the huge consumption of CPUs. Any relief planned before the current crop of puzzles expire?

tamirh's picture
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Joined: 05/11/2012

We should have the fix out in devprev later today and into main as soon as possible after that.

Joined: 09/21/2011
Groups: Void Crushers

This was 2 days ago. When do we get it? This puzzle is much slower then the big 678.

tamirh's picture
User offline. Last seen 8 years 33 weeks ago. Offline
Joined: 05/11/2012

Sorry about that, a few things came up with one of the changes we wanted to get out to devprev.

We normally try not to push a new version late in the week but I think it would be good to get this out today. I'll try and get it out later today so you can work with the new version over the weekend.

brow42's picture
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Joined: 09/19/2011
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I just started this puzzle, and I went to reset all the residues back to alanine with a script. It changed about 1 residue per second.

Joined: 09/21/2011
Groups: Void Crushers

It is still a pretty slow puzzle when using devprev. But not so extreme slow as it was. Mutate combo is now usable, before the second phase took forever.


Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons