puzzle picture
676 (<15): 76 Residue Monomer Freestyle
Status: Closed

Summary

Name: 676 (<15): 76 Residue Monomer Freestyle
Status: Closed
Created: 02/14/2013
Points: 100
Expired: 02/28/2013 - 09:00
Difficulty: Beginner
Description: We are giving you a single chain of 76 residues to design. Nearing the end of this puzzle, we will post a 76 residue symmetric dimer puzzle where you will be able to load your solution from this monomer into the dimer. Keep that in mind when you are designing your monomer. There are four filters enabled on this puzzle. The ResidueIE filter ensures PHY, TYR, and TRP residues are scoring well. The 1st LayerScore filter ensures the number of residues in the core is between 30% and 70%. The 2nd LayerScore filter ensures the number of residues on the surface is between 30% and 70%. The 3rd LayerScore filter ensures the number of boundary (residues between the core and surface) residues is below 70%. We hope these filters will help you design proteins that the scientists will be able to create in the lab. For players with fewer than 15 global points.
Categories: Beginner

Top Groups

RankGroupScorePoints
1Russian team10,860100
2Team Texas10,80360
3Team China9,78933
4Minions of TWIS6,64617
5NTAHS6,6408

Top Soloists

RankPlayerGroupScorePoints
1CheezWhiz 78 1437  10,900100
2Lecc 78 1437 Russian team10,860100
3ManVsYard 8 108 10,80399
4eromana 78 818  10,78698
5Part1Zan 78 1437 Russian team10,77897


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Comments

tamirh's picture
User offline. Last seen 6 years 13 weeks ago. Offline
Joined: 05/11/2012
More info here:

The Layer Score filter ensures the proteins will fold up into desirable and realistic shapes. It will categorize each backbone residue as either 'core', 'surface', or 'boundary'. If you think of the protein as being suspended in a liquid, the 'surface' residues are those most exposed to the liquid. Subsequently, the 'core' residues are those that are most protected and the 'boundary' residues are the ones that lie between the 'core' and the 'surface'. Most residues are categorized as either 'core' or 'surface'.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons