puzzle picture
676: 76 Residue Monomer Freestyle
Status: Closed


Name: 676: 76 Residue Monomer Freestyle
Status: Closed
Created: 02/14/2013
Points: 100
Expired: 02/28/2013 - 09:00
Difficulty: Beginner
Description: We are giving you a single chain of 76 residues to design. Nearing the end of this puzzle, we will post a 76 residue symmetric dimer puzzle where you will be able to load your solution from this monomer into the dimer. Keep that in mind when you are designing your monomer. There are four filters enabled on this puzzle. The ResidueIE filter ensures PHY, TYR, and TRP residues are scoring well. The 1st LayerScore filter ensures the number of residues in the core is between 30% and 70%. The 2nd LayerScore filter ensures the number of residues on the surface is between 30% and 70%. The 3rd LayerScore filter ensures the number of boundary (residues between the core and surface) residues is below 70%. We hope these filters will help you design proteins that the scientists will be able to create in the lab.
Categories: Design, Overall

Top Groups

1Void Crushers11,398100
2Anthropic Dreams11,38886
4Beta Folders11,28863

Top Evolvers

Top Soloists

Need this puzzle? Log in to download.  


tamirh's picture
User offline. Last seen 9 years 9 weeks ago. Offline
Joined: 05/11/2012
More info here:

The Layer Score filter ensures the proteins will fold up into desirable and realistic shapes. It will categorize each backbone residue as either 'core', 'surface', or 'boundary'. If you think of the protein as being suspended in a liquid, the 'surface' residues are those most exposed to the liquid. Subsequently, the 'core' residues are those that are most protected and the 'boundary' residues are the ones that lie between the 'core' and the 'surface'. Most residues are categorized as either 'core' or 'surface'.

User login
Download links:
  Windows    OSX    Linux  
(10.12 or later)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media

Only search fold.it
Other Games: Mozak
Recommend Foldit
Top New Users

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons