puzzle picture
670: 30 Residue Symmetric Dimer of Dimers Freestyle Retry
Status: Closed


226firejuggler 60 1163 Void Crushers10,6642
227guineapig 39 23  10,6562
228flyflipper102 60 2065  10,6552
229brianmtoy 60 2065  10,6532
230versat82 60 661 Piratenpartei Deutschland10,6422
231evilgrinners 60 2065  10,6342
232steamywindow 60 2065  10,6322
233monkry 60 2065  10,6242
234LociOiling 3 1  10,6212
235siyuchen 60 2065  10,5992
236AIDA64 60 2065  10,5992
237NR22 60 2065  10,5952
238kmf1016 60 2065  10,5882
239bob1928 60 2065  10,5872
240mottiger 60 2065 Anthropic Dreams10,5742
241Alex333 60 121  10,5662
242mirrax 60 2065  10,5642
243dflear 60 2065 Anthropic Dreams10,5602
244Jobriq 60 2065 Gargleblasters10,5602
245tailsforever 60 2065  10,5472
246navn 60 2065  10,5192
247Thooliv 60 2065  10,5142
248eee789 60 2065  10,4881
249griever41269 60 2065  10,4841
250dpl 60 2065  10,4811

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tamirh's picture
User offline. Last seen 8 years 32 weeks ago. Offline
Joined: 05/11/2012
More info here:

This puzzle will have two filters enabled, the Residue IE and the Layer Score filter. If you look under your score, there will be a message similar to "No bonuses, 1 penalty acquired, all conditions met". If you click on the > arrow you will get more information about these filters.

The Layer Score filter is a new filter designed to ensure proteins fold up into desirable shapes. It will categorize each backbone residue as either 'core', 'surface', or 'boundary'. If you think of the protein as being suspended in a liquid, the 'surface' residues are those most exposed to the liquid. Subsequently, the 'core' residues are those that are most protected and the 'boundary' residues are the ones that lie between the 'core' and the 'surface'. Most residues are categorized as either 'core' or 'surface'.

In this puzzle, the filter requires 30% of your protein residues to be in the 'core'. If you do not meet this criteria, you will lose points. If you are losing points, you can click the 'Show' button in the filters dropdown below the score and it will highlight all of the residues that are on the surface and how many you still need to move into the 'core'.

tamirh's picture
User offline. Last seen 8 years 32 weeks ago. Offline
Joined: 05/11/2012

You will need the updated client (released 01/16) to play this puzzle.

There is a bug where using 'Show expected residue burial' will cause instability with this puzzle.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons