puzzle picture
670: 30 Residue Symmetric Dimer of Dimers Freestyle Retry
Status: Closed


176Schnecke 70 1803  11,2077
177cobaltteal 70 1803  11,2046
178stomjoh 70 42  11,1826
179SouperGenious 70 1803  11,1786
180birdy_ssr 70 1803  11,1656
181Xanthie 70 1803  11,1636
182GenVeers 70 1803  11,1616
183weitzen 70 1803  11,1596
184utaca 70 1803 Void Crushers11,1586
185adtewa 70 1803  11,1415
186diamond_dust 70 1803  11,1325
187Crossed Sticks 70 65  11,1255
188sbea3 70 1803  11,0985
189mirjamvandelft 70 1803  11,0565
190WBarme1234 70 40  11,0525
191NAHA3 70 1803  11,0485
192Broussaille 70 1803  11,0485
193gcm24 70 1803  11,0425
194Tac1 70 1803  11,0355
195kdieber 70 1803  11,0254
196rawkuts 70 1803 null pointer exception11,0194
197LuapNor 70 1803 10,9874
198MihoK 70 1803  10,9844
199SnoopySnoopy 70 1803  10,9834
200GreekCivilization 70 1803  10,9674

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tamirh's picture
User offline. Last seen 8 years 24 weeks ago. Offline
Joined: 05/11/2012
More info here:

This puzzle will have two filters enabled, the Residue IE and the Layer Score filter. If you look under your score, there will be a message similar to "No bonuses, 1 penalty acquired, all conditions met". If you click on the > arrow you will get more information about these filters.

The Layer Score filter is a new filter designed to ensure proteins fold up into desirable shapes. It will categorize each backbone residue as either 'core', 'surface', or 'boundary'. If you think of the protein as being suspended in a liquid, the 'surface' residues are those most exposed to the liquid. Subsequently, the 'core' residues are those that are most protected and the 'boundary' residues are the ones that lie between the 'core' and the 'surface'. Most residues are categorized as either 'core' or 'surface'.

In this puzzle, the filter requires 30% of your protein residues to be in the 'core'. If you do not meet this criteria, you will lose points. If you are losing points, you can click the 'Show' button in the filters dropdown below the score and it will highlight all of the residues that are on the surface and how many you still need to move into the 'core'.

tamirh's picture
User offline. Last seen 8 years 24 weeks ago. Offline
Joined: 05/11/2012

You will need the updated client (released 01/16) to play this puzzle.

There is a bug where using 'Show expected residue burial' will cause instability with this puzzle.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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