puzzle picture
670: 30 Residue Symmetric Dimer of Dimers Freestyle Retry
Status: Closed

Soloists

RankPlayerGroupScorePoints
151Tyggy Too 69 1797 Anthropic Dreams11,43210
152Ben666 69 1797  11,43110
153Bushman 69 1797  11,42210
154spocksbrain 69 1797  11,41910
155arcsign 69 1797  11,40810
156KingLear 69 1797  11,4089
157mnucer 69 1797  11,3709
158mitarcher 69 1797  11,3689
159tela 69 1797  11,3569
160limda 69 1797  11,3499
161decbin 69 1797  11,3269
162natatafish 69 1797  11,3078
163MalcolmW 69 1797  11,3028
164momadoc 69 729  11,2748
165born2d 69 1797  11,2728
166jecauril 69 1797  11,2668
167telesphore4 69 1797  11,2628
168hayabuta 69 1797  11,2568
169JunoNH 69 1797  11,2557
170parsnip 69 222  11,2417
171dbuske 69 1797 Gargleblasters11,2387
172Azukay 69 1797 Go Science11,2347
173rarkenin 69 1797  11,2287
174hkilik 69 1797  11,2227
175bendbob 69 1797 Anthropic Dreams11,2197


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Comments

tamirh's picture
User offline. Last seen 8 years 24 weeks ago. Offline
Joined: 05/11/2012
More info here:

This puzzle will have two filters enabled, the Residue IE and the Layer Score filter. If you look under your score, there will be a message similar to "No bonuses, 1 penalty acquired, all conditions met". If you click on the > arrow you will get more information about these filters.

The Layer Score filter is a new filter designed to ensure proteins fold up into desirable shapes. It will categorize each backbone residue as either 'core', 'surface', or 'boundary'. If you think of the protein as being suspended in a liquid, the 'surface' residues are those most exposed to the liquid. Subsequently, the 'core' residues are those that are most protected and the 'boundary' residues are the ones that lie between the 'core' and the 'surface'. Most residues are categorized as either 'core' or 'surface'.

In this puzzle, the filter requires 30% of your protein residues to be in the 'core'. If you do not meet this criteria, you will lose points. If you are losing points, you can click the 'Show' button in the filters dropdown below the score and it will highlight all of the residues that are on the surface and how many you still need to move into the 'core'.

tamirh's picture
User offline. Last seen 8 years 24 weeks ago. Offline
Joined: 05/11/2012
Notes:

You will need the updated client (released 01/16) to play this puzzle.

There is a bug where using 'Show expected residue burial' will cause instability with this puzzle.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons