puzzle picture
670: 30 Residue Symmetric Dimer of Dimers Freestyle Retry
Status: Closed


351hippichic 45 1438  8,5551
352Taxman82 45 1438  8,5091
353jmuirW 45 1438  8,5061
354candylord 45 1438  8,4771
355Shelena 45 1438  8,4551
356Jesin 45 1438  8,4411
357sjoerdouwe 45 1438  8,3721
358PlagueRat 45 1438 Androids8,3721
359mberna00 45 1438 Anthropic Dreams8,3661
360thorsten_osaka 45 1438  8,3631
361Random_Meh 45 1438  8,2931
362blitz561 45 1438  8,2631
363dudygarganel 45 1438  8,2561
364lemoni98 45 1438  8,2351
365cvb389 45 1438 8,1001
366Thrianya 45 1438  8,0711
367Nob_____ 45 1438  8,0531
368foldthestuffman 45 1438  8,0531
369ShadowBlade 45 1438  8,0531
370heyubob 45 351  8,0531
371bluewolf55 45 1438  8,0531
372hayange 45 1438  8,0531
373brofessor 45 1438 Storm8,0531
374hooooa 45 1438  8,0521
375weurhartdezirez 45 1438 Freedom Folders8,0521

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tamirh's picture
User offline. Last seen 8 years 48 weeks ago. Offline
Joined: 05/11/2012
More info here:

This puzzle will have two filters enabled, the Residue IE and the Layer Score filter. If you look under your score, there will be a message similar to "No bonuses, 1 penalty acquired, all conditions met". If you click on the > arrow you will get more information about these filters.

The Layer Score filter is a new filter designed to ensure proteins fold up into desirable shapes. It will categorize each backbone residue as either 'core', 'surface', or 'boundary'. If you think of the protein as being suspended in a liquid, the 'surface' residues are those most exposed to the liquid. Subsequently, the 'core' residues are those that are most protected and the 'boundary' residues are the ones that lie between the 'core' and the 'surface'. Most residues are categorized as either 'core' or 'surface'.

In this puzzle, the filter requires 30% of your protein residues to be in the 'core'. If you do not meet this criteria, you will lose points. If you are losing points, you can click the 'Show' button in the filters dropdown below the score and it will highlight all of the residues that are on the surface and how many you still need to move into the 'core'.

tamirh's picture
User offline. Last seen 8 years 48 weeks ago. Offline
Joined: 05/11/2012

You will need the updated client (released 01/16) to play this puzzle.

There is a bug where using 'Show expected residue burial' will cause instability with this puzzle.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons