puzzle picture
670: 30 Residue Symmetric Dimer of Dimers Freestyle Retry
Status: Closed


301frostschutz 53 511  9,4801
302crawlee34225 60 2065  9,4531
303 katfish 60 2065  9,4481
3043.14origami 60 2065  9,4351
305NyteShade 60 2065 Void Crushers9,4081
306tuvas21 60 2065  9,3971
307Reuben 60 2065  9,3581
308Don Don 60 2065  9,3401
309otong1 60 345 L'Alliance Francophone9,3221
310gwanfried 60 2065  9,3221
311galactobourico 60 2065  9,2641
312Hubsi 60 2065  9,2631
313mz84 60 2065  9,2371
314Lendsheep 60 2065  9,2131
315ingebean 60 2065  9,1441
316LostLogia4 60 2065  9,1141
317Ditti123 60 2065 7Monkeys9,1051
318EdC 60 2065  9,0931
319rufmemory 60 2065  9,0901
320cassandraberry81897 60 2065 Beta Folders9,0721
321Quackers 60 2065  9,0621
322Chris67 60 2065  9,0491
323greenmachine 60 2065  9,0461
324carbon5678 60 2065  9,0411
325Swiper 60 2065  9,0311

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tamirh's picture
User offline. Last seen 8 years 32 weeks ago. Offline
Joined: 05/11/2012
More info here:

This puzzle will have two filters enabled, the Residue IE and the Layer Score filter. If you look under your score, there will be a message similar to "No bonuses, 1 penalty acquired, all conditions met". If you click on the > arrow you will get more information about these filters.

The Layer Score filter is a new filter designed to ensure proteins fold up into desirable shapes. It will categorize each backbone residue as either 'core', 'surface', or 'boundary'. If you think of the protein as being suspended in a liquid, the 'surface' residues are those most exposed to the liquid. Subsequently, the 'core' residues are those that are most protected and the 'boundary' residues are the ones that lie between the 'core' and the 'surface'. Most residues are categorized as either 'core' or 'surface'.

In this puzzle, the filter requires 30% of your protein residues to be in the 'core'. If you do not meet this criteria, you will lose points. If you are losing points, you can click the 'Show' button in the filters dropdown below the score and it will highlight all of the residues that are on the surface and how many you still need to move into the 'core'.

tamirh's picture
User offline. Last seen 8 years 32 weeks ago. Offline
Joined: 05/11/2012

You will need the updated client (released 01/16) to play this puzzle.

There is a bug where using 'Show expected residue burial' will cause instability with this puzzle.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons