puzzle picture
670: 30 Residue Symmetric Dimer of Dimers Freestyle Retry
Status: Closed


276TOBUTORI 60 2063  10,1231
277multaq 60 397 L'Alliance Francophone10,1191
278ZeonC 60 2063  10,1041
279cijcj 60 2063  10,0901
280keithprimmer 60 2063  10,0901
281dentao 60 2063  10,0771
282denise1 60 2063  10,0481
283wosser1 60 2063  10,0441
284Matthew41 60 2063  10,0001
285Cyberkashi 41 618  9,9781
286Flimsor 60 2063 Aviation High School9,9621
287rinze 60 57  9,9381
288nmos1056 60 2063  9,9241
289perrystaff 60 2063  9,9111
290trainboy 60 2063 DNA Masters9,8831
291Steve001 60 2063 Anthropic Dreams9,8721
292DrMistry 60 2063  9,8681
293deLaCeiba 60 2063  9,7901
294Cyzaki 60 2063 Foldit UK9,7891
295GioB 60 2063  9,7781
296BCAA 60 2063  9,7781
297roman madala 60 320  9,6531
298Astrophysicist5... 60 2063  9,5981
299rsvp 60 2063  9,5691
300Bobslede 60 2063  9,5151

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tamirh's picture
User offline. Last seen 8 years 32 weeks ago. Offline
Joined: 05/11/2012
More info here:

This puzzle will have two filters enabled, the Residue IE and the Layer Score filter. If you look under your score, there will be a message similar to "No bonuses, 1 penalty acquired, all conditions met". If you click on the > arrow you will get more information about these filters.

The Layer Score filter is a new filter designed to ensure proteins fold up into desirable shapes. It will categorize each backbone residue as either 'core', 'surface', or 'boundary'. If you think of the protein as being suspended in a liquid, the 'surface' residues are those most exposed to the liquid. Subsequently, the 'core' residues are those that are most protected and the 'boundary' residues are the ones that lie between the 'core' and the 'surface'. Most residues are categorized as either 'core' or 'surface'.

In this puzzle, the filter requires 30% of your protein residues to be in the 'core'. If you do not meet this criteria, you will lose points. If you are losing points, you can click the 'Show' button in the filters dropdown below the score and it will highlight all of the residues that are on the surface and how many you still need to move into the 'core'.

tamirh's picture
User offline. Last seen 8 years 32 weeks ago. Offline
Joined: 05/11/2012

You will need the updated client (released 01/16) to play this puzzle.

There is a bug where using 'Show expected residue burial' will cause instability with this puzzle.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons