puzzle picture
664 (<15): Unlocked Frizzled Design Puzzle
Status: Closed

Summary

Name: 664 (<15): Unlocked Frizzled Design Puzzle
Status: Closed
Created: 12/29/2012
Points: 100
Expired: 01/09/2013 - 11:00
Difficulty: Beginner
Description: This is a the same protein as Puzzle 640 (Frizzled with a wider pocket than Puzzle 659) but this time the helix is unlocked. You can mutate any residue on the helix but none on Frizzled. We still have the new "Residue Interaction Energy" filter. Natural proteins avoid putting Tryptophan, Phenylalanine, and Tyrosine on the surface. However, Foldit often gives a score bonus if you load up the surface of your design with Tryptophan. The ResidueIE filter helps to counteract that, helping you make more useful designs. More details in the puzzle comments. For players with fewer than 15 global points.
Categories: Beginner

Top Groups

RankGroupScorePoints
1Gargleblasters10,1660
2Czech National Team10,1640
3Ukraine10,1570
4Sweden10,1470
5sjmp10,1450

Top Soloists

RankPlayerGroupScorePoints
1AlexBiohazardous 79 1463  10,198100
2SN2003dh 79 1463  10,19699
3JasonPouris 79 1463  10,19397
4chrisb41 79 1463  10,19095
5abrakadabra 79 1463  10,18993


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Comments

beta_helix's picture
User offline. Last seen 2 days 7 hours ago. Offline
Joined: 05/09/2008
Groups: None
Check out the blogpost

for more information about this puzzle:
http://fold.it/portal/node/993721

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons