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664: Unlocked Frizzled Design Puzzle
Status: Closed

Summary

Name: 664: Unlocked Frizzled Design Puzzle
Status: Closed
Created: 12/29/2012
Points: 100
Expired: 01/09/2013 - 11:00
Difficulty: Beginner
Description: This is a the same protein as Puzzle 640 (Frizzled with a wider pocket than Puzzle 659) but this time the helix is unlocked. You can mutate any residue on the helix but none on Frizzled. We still have the new "Residue Interaction Energy" filter. Natural proteins avoid putting Tryptophan, Phenylalanine, and Tyrosine on the surface. However, Foldit often gives a score bonus if you load up the surface of your design with Tryptophan. The ResidueIE filter helps to counteract that, helping you make more useful designs. More details in the puzzle comments.
Categories: Design, Overall

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Comments

beta_helix's picture
User offline. Last seen 2 days 3 hours ago. Offline
Joined: 05/09/2008
Groups: None
Throwing a wrench at cancer Blogpost

Please read the blogpost about how this puzzle could help us fight cancer: http://fold.it/portal/node/993721

Scientist Chat transcript: http://fold.it/portal/node/992895
Original Blogpost (about the Frizzled protein with the more narrow pocket): http://fold.it/portal/node/992888

beta_helix's picture
User offline. Last seen 2 days 3 hours ago. Offline
Joined: 05/09/2008
Groups: None
residueIE in locked regions

We are aware of the fact that the residueIE filter complains about certain residues on the surface of the native Frizzled protein (this has been brought up before:
http://fold.it/portal/node/993602#comment-20813 ) but unfortunately the fix for this isn't in the latest update, so you'll have to ignore those for now.

This is similar to any clashes you ever find in locked regions: every player will have them and there is nothing that you can do about it, so it's best to just ignore them for now.

(But we realize that it is annoying to see those negative scores, so in the future we will try to get rid of them).

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons