doesn't open.

Case number:845829-993998
Opened by:MalcolmW
Opened on:Saturday, December 1, 2012 - 02:39
Last modified:Wednesday, December 5, 2012 - 00:12

I no longer have access to as it refuses to open after the last update.
I am using an iMac with intel dual core processor 2.4 GHz with 4GB Ram and OS X 10.5.8
When I try to open the programme nothing happens and no error message appears.
I tried reinstalling the file and on completion it loads the update and just does absolutely nothing after the download window closes. So I am still unable to open it.
Can someone please help me as latest update has stopped my protein folding which I was really enjoying.

Here's the log.text which says "Can't open options file options.txt." I don't know what this means.
Can someone please help??????

args passed:
Can't open options file options.txt. (/Users/jflat06/foldit/mini-interactive-main/rosetta_source/xcode/../src/interactive/application/
core.init: Mini-Rosetta version 49434M from
core.init: command: /Users/malcolm/Downloads/ -database cmp-database-f8e2849dd8fb7589266fa139195d64af/rosetta_database -resources cmp-resources-1b38a6973c80aef2c033b845c0465b0d/resources -interactive_game novice -boinc_url
core.init: 'RNG device' seed mode, using '/dev/urandom', seed=501598014 seed_offset=0 real_seed=501598014
core.init.random: RandomGenerator:init: Normal mode, seed=501598014 RG_type=mt19937
starting the init thread!..
boinc base url:
checking updates...
local: 'aec90e9464e1880db1a66e7baca7c585'
remote: '214ef62a78b8494a860799e510e24eb0'
local: 'f8e2849dd8fb7589266fa139195d64af'
remote: 'f8e2849dd8fb7589266fa139195d64af'
local: '1b38a6973c80aef2c033b845c0465b0d'
remote: '2f1235b9563201ec9fe71d3ae352c9bf'
cleaning up downloads:

(Sat, 12/01/2012 - 02:39  |  12 comments)

Joined: 04/19/2009

I have heard of 2 others with this problem - it looks as if the update made the program incompatible with OS 10.4 & 10.5

beta_helix's picture
User offline. Last seen 1 hour 30 min ago. Offline
Joined: 05/09/2008
Groups: None

Is this the latest update to main on 11/21/2012:
or yesterday's developer preview update? 11/30/2012:


Joined: 04/19/2009

It's the latest Main update (from what I have heard).

phi16's picture
User offline. Last seen 49 min 35 sec ago. Offline
Joined: 12/23/2008

I would have made the identical entry but with OS 10.4.11. This occurred on 11/21/12. It's the last system upgrade available to that machine which otherwise is not a bad machine (too old) nor deserves being thrown out albeit has now had five birthdays.

This is the computer at my Dad's house that has kept me sane these many years, allowing me to fold while visiting with Dad. Without it, I don't know what I will do or what will happen. I could wind up in rehab or therapy which would cost thousands and still not get at the root cause. Please, please. If there is anything you can do to forestall the day when will no longer run there, please help me now.


tamirh's picture
User offline. Last seen 6 years 23 weeks ago. Offline
Joined: 05/11/2012

Currently looking into what happened that broke with older osx versions. Thanks for finding this.

jflat06's picture
User offline. Last seen 1 week 3 days ago. Offline
Joined: 09/29/2010
Groups: Window Group

I'm releasing an update soon which should fix this for devprev. We'll try to get it pushed out to main as soon as possible.

jj_pet's picture
User offline. Last seen 6 years 48 weeks ago. Offline
Joined: 11/15/2012
Groups: None

yes same story here... I just got started, the 2nd time i loged in on my 10.5.8 ox mac the system updated the app and then, nothing... has this bee resolved?

jflat06's picture
User offline. Last seen 1 week 3 days ago. Offline
Joined: 09/29/2010
Groups: Window Group

The problem has been resolved in the devprev update group only. We will have to address the other issues with the developer preview before we can push this out to main. If you are interested in trying out the developer preview, you can find instructions on the FAQ here:

Joined: 04/19/2009

Because of the occasional problem like this

Perhaps its time to find a way to allow users to rollback their client?

If I were on my other computer, I would probably have it also, it's an older machine running 10.5.

Joined: 04/18/2012
Groups: None

A rollback is a good idea, but I hope Foldit doesn't leave leopard in the dark. Thanks for your replies, Malcolm ;):)

Joined: 04/18/2012
Groups: None

Thanks for the link, looks like I'll have to edit options.txt to devprev and see if that works. Meanwhile I'm just playing EteRNA where my global rank is now #47. It would be interesting if Foldit also had a global rank too, as it's difficult to comprehend how well I'm doing on the protein folding.
Malcolm ;):)

alwen's picture
User offline. Last seen 1 day 30 min ago. Offline
Joined: 10/03/2011

Having freshly downloaded mine, now it won't open (Win 7, main) either.

Log.txt: (lot of unhandled exceptions there at the end)

args passed:
core.init: Mini-Rosetta version 52243M from
core.init: command: C:\FoldIt\Foldit.exe -database cmp-database-f8e2849dd8fb7589266fa139195d64af/rosetta_database -resources cmp-resources-2f1235b9563201ec9fe71d3ae352c9bf/resources -interactive_game novice -boinc_url
core.init: 'RNG device' seed mode, using 'CryptGenRandom', seed=118763299 seed_offset=0 real_seed=118763299
core.init.random: RandomGenerator:init: Normal mode, seed=118763299 RG_type=mt19937
starting the init thread!..
boinc base url:
checking updates...
local: '7050e4fdfd6c421c68170f49a5bff5c7'
remote: '7050e4fdfd6c421c68170f49a5bff5c7'
local: 'f8e2849dd8fb7589266fa139195d64af'
remote: 'f8e2849dd8fb7589266fa139195d64af'
local: '2f1235b9563201ec9fe71d3ae352c9bf'
remote: '2f1235b9563201ec9fe71d3ae352c9bf'
cleaning up old components:
binary 00000000000000000000000000000000
binary 7050e4fdfd6c421c68170f49a5bff5c7
binary ead2cfed9bcd69a74da4c007f4264bfa
database f8e2849dd8fb7589266fa139195d64af
resources 00000000000000000000000000000000
resources 1b38a6973c80aef2c033b845c0465b0d
resources 2f1235b9563201ec9fe71d3ae352c9bf
SoundTheme::load: cmp-resources-2f1235b9563201ec9fe71d3ae352c9bf\resources\sounds/organic_01
loading: cmp-resources-2f1235b9563201ec9fe71d3ae352c9bf\resources\sounds/organic_01/rotamer_land_00.ogg
loading: cmp-resources-2f1235b9563201ec9fe71d3ae352c9bf\resources\sounds/organic_01/rotamer_land_01.ogg
loading: cmp-resources-2f1235b9563201ec9fe71d3ae352c9bf\resources\sounds/organic_01/rotamer_land_02.ogg
loading: cmp-resources-2f1235b9563201ec9fe71d3ae352c9bf\resources\sounds/organic_01/rotamer_land_03.ogg
loading: cmp-resources-2f1235b9563201ec9fe71d3ae352c9bf\resources\sounds/organic_01/rotamer_land_04.ogg
loading: cmp-resources-2f1235b9563201ec9fe71d3ae352c9bf\resources\sounds/organic_01/rotamer_land_05.ogg
SVM classifier successfully loaded
Feature list successfully loaded
Valid classifier feature list
buildid: 2012-11-19-52243M-win_x86
about to create view_options_button_
Duplicate hotkey Shift+L (Show outlines, )
setting side chain mode to: 1 Show Stubs
Playing: sounds/organic_01/splashscreen.ogg
Converting any old-style quicksaves and autosaves...
core.chemical.ResidueTypeSet: Finished initializing fa_standard residue type set. Created 9697 residue types
core.chemical.ResidueTypeSet: Finished initializing centroid residue type set. Created 3780 residue types
core.scoring.etable: Starting energy table calculation
core.scoring.etable: smooth_etable: changing atr/rep split to bottom of energy well
core.scoring.etable: smooth_etable: spline smoothing lj etables (maxdis = 6)
core.scoring.etable: smooth_etable: spline smoothing solvation etables (max_dis = 6)
core.scoring.etable: Finished calculating energy tables. Database file opened: scoring/score_functions/PairEPotential/pdb_pair_stats_fine Database file opened: scoring/score_functions/hbonds/standard_params/HBPoly1D.csv Database file opened: scoring/score_functions/hbonds/standard_params/HBFadeIntervals.csv
standard_params Database file opened: scoring/score_functions/hbonds/standard_params/HBEval.csv Database file opened: scoring/score_functions/EnvPairPotential/env_log.txt Database file opened: scoring/score_functions/EnvPairPotential/cbeta_den.txt Database file opened: scoring/score_functions/EnvPairPotential/pair_log.txt Database file opened: scoring/score_functions/EnvPairPotential/cenpack_log.txt Database file opened: scoring/score_functions/EnvPairPotential/env_log.txt Database file opened: scoring/score_functions/EnvPairPotential/cbeta_den.txt Database file opened: scoring/score_functions/EnvPairPotential/pair_log.txt Database file opened: scoring/score_functions/EnvPairPotential/cenpack_log.txt Database file opened: scoring/score_functions/MembranePotential/CEN6_mem_env_log.txt Database file opened: scoring/score_functions/MembranePotential/CEN10_mem_env_log.txt Database file opened: scoring/score_functions/MembranePotential/memcbeta_den.txt Database file opened: scoring/score_functions/MembranePotential/mem_pair_log.txt Database file opened: scoring/score_functions/P_AA_pp/P_AA Database file opened: scoring/score_functions/P_AA_pp/P_AA_n Database file opened: scoring/score_functions/P_AA_pp/P_AA_pp Database file opened: scoring\score_functions\rama\Rama_smooth_dyn.dat_ss_6.4
core.fragment.picking_old.vall.vall_io: Reading Vall library from cmp-database-f8e2849dd8fb7589266fa139195d64af\rosetta_database\sampling/vall.small.dat.2001-02-02 ...
core.fragment.picking_old.vall.vall_io: ... done. Read 50000 lines. Time elapsed: 2 seconds.
core.fragment.picking_old.vall.vall_io: Prior library contained 0 sections totaling 0 residues.
core.fragment.picking_old.vall.vall_io: Added 268 sections to library totaling 50000 residues.
Reading in vall_torsions file: cmp-database-f8e2849dd8fb7589266fa139195d64af\rosetta_database\chemical/rna/1jj2.torsions
Lines read from vall_torsions file: 2754
About to show the puzzle screen...
Trying to get the puzzle list...
Loading cache...
Parsing puzzle URL...
Parsing contests...
Parsing macros...
Saving the cache...
Parsing level completion...
Initting the list...
Got the puzzles...
Finished show_puzzle_screen...
has key .density
core.scoring.electron_density.ElectronDensity: Loading Density Map
core.scoring.electron_density.ElectronDensity: Setting resolution to 1A
core.scoring.electron_density.ElectronDensity: atom mask to 3.2A
core.scoring.electron_density.ElectronDensity: CA mask to 6A
core.scoring.electron_density.ElectronDensity: Read density map'0000993970.ir_puzzle.density'
core.scoring.electron_density.ElectronDensity: extent: 52 x 81 x 69
core.scoring.electron_density.ElectronDensity: origin: 170 x 2 x 16
core.scoring.electron_density.ElectronDensity: altorigin: 0 x 0 x 0
core.scoring.electron_density.ElectronDensity: grid: 90 x 90 x 360
core.scoring.electron_density.ElectronDensity: celldim: 66.285 x 66.285 x 253.831
core.scoring.electron_density.ElectronDensity: cellangles: 90 x 90 x 120
core.scoring.electron_density.ElectronDensity: crs2xyz: 3 x 2 x 1
core.scoring.electron_density.ElectronDensity: symBytes: 0
MINMULT: 2 2 2
core.scoring.electron_density.ElectronDensity: Resizing 90x90x360 to 66x66x256
core.scoring.electron_density.ElectronDensity: new extent: 66 x 66 x 256
core.scoring.electron_density.ElectronDensity: new origin: 11.7333 x 1.46667 x 120.889
core.scoring.electron_density.ElectronDensity: new grid: 66 x 66 x 256
core.scoring.electron_density.ElectronDensity: max_del_grid =1.00432
core.scoring.electron_density.ElectronDensity: Density map stats:
core.scoring.electron_density.ElectronDensity: min = -6.84658
core.scoring.electron_density.ElectronDensity: max = 30.3712
core.scoring.electron_density.ElectronDensity: mean = -0.000395242
core.scoring.electron_density.ElectronDensity: stdev = 0.840538
core.scoring.electron_density.ElectronDensity: CoM = 21.6455 , 33.0389 , 22.1951
core.scoring.electron_density.ElectronDensity: xform = 33.1425 , 57.4045 , 253.831
core.scoring.electron_density.ElectronDensity: efforig = 11.7333 , 1.46667 , 120.889
has key .owts_patch
has key .opdb
core.scoring.electron_density.FastDensEnergy: Creating new one-to-all energy container (115)
core.scoring.electron_density.ElectronDensity: Resizing 66x66x256 to 132x132x512

1: RaiseException +88 bytes (no line)
2: library_main +23620733 bytes (no line)
3: library_main +23620660 bytes (no line)
4: library_main +5488169 bytes (no line)
5: library_main +5492570 bytes (no line)
6: library_main +23108984 bytes (no line)
7: library_main +17132906 bytes (no line)
8: library_main +17136431 bytes (no line)
9: library_main +18995469 bytes (no line)
10: library_main +16799758 bytes (no line)
11: library_main +16812539 bytes (no line)
12: library_main +4099255 bytes (no line)
13: library_main +2336342 bytes (no line)
14: library_main +1376723 bytes (no line)
15: library_main +1383240 bytes (no line)
16: library_main +4213838 bytes (no line)
17: library_main +4216982 bytes (no line)
18: BaseThreadInitThunk +18 bytes (no line)
19: RtlInitializeExceptionChain +99 bytes (no line)
20: RtlInitializeExceptionChain +54 bytes (no line)


Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons