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656: 40 Residue Symmetric Trimer Retry
Status: Closed

Summary

Name: 656: 40 Residue Symmetric Trimer Retry
Status: Closed
Created: 11/21/2012
Points: 100
Expired: 11/29/2012 - 23:00
Difficulty: Advanced
Description: This is a small (40 residue) symmetric trimer design puzzle. It is the same as 623 except the Residue Interaction Energy filter is enabled. This filter will give a score bonus or penalty based on how well your residues are scoring compared to expected values. Remember, a symmetric protein relies not only on how well folded each part is, but also on how well they interface together - and a symmetric trimer can be thought of as having three 2-fold interfaces. Stay tuned for higher-order symmetries, like tetrahedra and octahedra!
Categories: Design, Overall, Symmetry

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Comments

bertro's picture
User offline. Last seen 7 hours 49 min ago. Offline
Joined: 05/02/2011
Groups: Beta Folders
Filter enabled?

Are you sure the Residue Interaction Energy filter is enabled? Because I see lots of Tryptophans in my solution.

tamirh's picture
User offline. Last seen 6 years 4 days ago. Offline
Joined: 05/11/2012
It looks like it's enabled

Below your score there should be an arrow plus something that says "No bonuses, no penalties., all conditions met" (ignore the mis-punctuation) and click on the arrow.

You can click "Show" to see where (if any) of your residues are not scoring well through the Residue IE filter.

tamirh's picture
User offline. Last seen 6 years 4 days ago. Offline
Joined: 05/11/2012
-

If you upload a screenshot I can try to explain any seemingly odd behavior (or more likely I will ask one of the scientists).

bertro's picture
User offline. Last seen 7 hours 49 min ago. Offline
Joined: 05/02/2011
Groups: Beta Folders
-

There is nothing that shows and there are no penalties either. The message in blue says "Residue IE Score met(REQUIRED)

I have 11 Tryptophans in my solution so far.

Sorry no facility to upload a screenshot here (unlike the feedback pages).

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons