puzzle picture
653: CASP ROLL Target R0025
Status: Closed


Name: 653: CASP ROLL Target R0025
Status: Closed
Created: 11/13/2012
Points: 100
Expired: 11/23/2012 - 13:00
Difficulty: Intermediate
Description: Here is the next CASP ROLL target. We are again providing you with 3 templates for now, and will give you with some server predictions once they are released. More details about this CASP target are in the puzzle comments.
Categories: CASP ROLL, Overall, Prediction

Top Groups

1Anthropic Dreams11,498100
3Go Science11,23470
4L'Alliance Francophone11,18957
5Void Crushers11,17347

Top Evolvers

Top Soloists

Need this puzzle? Log in to download.  


Joined: 05/09/2008
Groups: None
Additional info about this CASP Roll target

Here is the CASP link for this target (showing the amino acid sequence):

You'll notice that the sequence we have given you has been trimmed (compared to the one on the CASP ROLL website). This is because the N-terminus is predicted to be a signal peptide by the Rosetta Server:

For more info on that: http://en.wikipedia.org/wiki/Signal_peptide

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valine at residue 104 is highly predicted to be part of a loop. However, the Valine at residue 47 is not predicted to be anything!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).

Link to template PDBs:

http://www.pdb.org/pdb/explore/explore.do?structureId=1sr3 http://www.pdb.org/pdb/explore/explore.do?structureId=4ex5 http://www.pdb.org/pdb/explore/explore.do?structureId=1qzg

Joined: 04/19/2009
I *hope* this is CASP Roll 0025

Since R0023 is due on the 16th?

Joined: 05/09/2008
Groups: None
Nice catch

Thanks auntdeen, indeed this is R0025 (and the links in the first comment are all correct)

w1ll's picture
User offline. Last seen 7 years 42 weeks ago. Offline
Joined: 11/16/2012
Groups: None
how do u play

how the heck do u play the game?

Joined: 05/09/2008
Groups: None

just press the button:

"Click here to start playing"

that is above the list of puzzles:

Download links:
  Windows    OSX    Linux  
(10.12 or later)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media

Other Games: Mozak
Only search fold.it
Recommend Foldit
User login
Top New Users

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons