652: 40 Residue Symmetry Dimer Retry

Summary

Name:

Status:

Closed

Created:

11/12/2012

Points:

100

Expired:

11/22/2012 - 23:00

Difficulty:

Advanced

Description:

This is a small (40 residue) symmetric dimer design puzzle. It is the same as 617 except there are two new features added to create better designs. The Residue IE (Interaction Energy) filter will give a bonus or penalty based on how well your residues are scoring compared to expected values. The LayerDesign filter will restrict the types of amino acids to encourage more realistic designs. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together; see the latest blogpost about this: http://fold.it/portal/node/993871

Categories:

Design, Overall, Symmetry

Rank

Group

Score

Points

Contenders

11,395

100

Anthropic Dreams

11,388

L'Alliance Francophone

11,364

Gargleblasters

11,268

Beta Folders

11,195

Rank

Player

Group

Score

Points

doug.ehlert 79 1607

Contenders

11,395

100

11,395

11,391

11,388

11,387

Rank

Player

Group

Score

Points

doug.ehlert 79 1607

Contenders

11,392

100

gmn 79 1607

Anthropic Dreams

11,386

goastano 79 1607

L'Alliance Francophone

11,359

MooMooMan 79 1607

Anthropic Dreams

11,335

Ch Garnier 79 1607

L'Alliance Francophone

11,327

Tue, 11/13/2012 - 04:52

tamirh 79 1607

Offline

Joined: 05/11/2012

Groups: null pointer exception

LayerDesign

For more info on the Layer Design filter, please see: http://fold.it/portal/node/993855

Tue, 11/20/2012 - 04:30

BootsMcGraw 79 1607

Offline

Joined: 12/06/2008

Groups: Contenders

Not realistic at all!

The filter will not allow me to place hydrophobes anywhere on a helix. I want to place hydrophobes in the area between two helices (the "inside"), while keeping the area to the outside of both hydrophilic. But no matter where I try to mutate a helix, it never lets me choose a hydrophobic, because all parts of a helix are apparently "outside".

I don't want to mutate my protein before I place it in some type of organized structure(s).

Am I doing something wrong, here? I am hearing cries like mine throughout chat. I really think the devs ned to re-consider how this filter works, or even if it we need it.

How about scoring "proper" sidechains better, but allowing us to mutate to whatever we think best?