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640: Frizzled Design Puzzle
Status: Closed


Name: 640: Frizzled Design Puzzle
Status: Closed
Created: 10/11/2012
Points: 100
Expired: 10/19/2012 - 23:59
Difficulty: Beginner
Description: You've seen this design puzzle before, but look more closely! The Frizzled protein occurs in a number of forms. Last time we gave you a form of Frizzled with a narrow pocket. This time we are giving you a form of Frizzled with a wider pocket. There are a couple of rules: You can mutate any residue on the helix but none on Frizzled and the small binding helix must stay in helical shape. We've also added a new filter that we call "Residue Interaction Energy". Natural proteins avoid putting Tryptophan, Phenylalanine, and Tyrosine on the surface. However, Foldit often gives a score bonus if you load up the surface of your design with Tryptophan. The Residue Interaction Energy filter helps to counteract that, helping you make better designs. Enjoy and thanks for all of your efforts!
Categories: Design, Overall

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2Go Science10,11785
3Anthropic Dreams10,11772
5Beta Folders10,11751

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1pauldunn 67 105 Go Science10,117100
2Aubade00 78 1941  10,11799
3jamiexq 75 88 Anthropic Dreams10,11797
4bertro 78 1941 foldeRNA10,11796
5pvc78 78 1941  10,11794

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons