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633: Return of the Tissue Regeneration Design Puzzle
Status: Closed

Summary

Name: 633: Return of the Tissue Regeneration Design Puzzle
Status: Closed
Created: 09/21/2012
Points: 100
Expired: 10/01/2012 - 05:00
Difficulty: Beginner
Description: We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. More details in the puzzle comments. Note: you will need the latest update to play this puzzle.
Categories: Design, Overall

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Comments

beta_helix's picture
User offline. Last seen 11 hours 32 min ago. Offline
Joined: 05/09/2008
Groups: None
More info here:

This is a repost of Puzzle 571: Tissue Regeneration Design Puzzle, but with a new filter that should help with the scoring artifacts that were prevalent in that puzzle.

More background on this puzzle can be found in the original blogpost: http://fold.it/portal/node/992888

gitwut's picture
User offline. Last seen 46 weeks 1 day ago. Offline
Joined: 05/18/2012
Groups: Contenders
Bonus/Condition area message

I'm seeing a message in the bonus/condition box message Residue IE Score: lost (-239)

I'm guessing that it might have something to do with the Helix integrity, but pulling the helix out and rebuilding it actually lowered the value to (-275). What exactly does this mean (also, what is "IE")? I have no idea how to fix it, though I'll continue to play with it.

I asked in global but no one else knew for sure.

I've clicked on the Show button (inside the box and beneath the message) and it obscures part of the protein as if it was sunk in an opaque red liquid.

tamirh's picture
User offline. Last seen 6 years 23 weeks ago. Offline
Joined: 05/11/2012
ResidueIE info

I posted on the forum some info explaining what ResidueIE is.

http://fold.it/portal/node/993602

Joined: 05/03/2009
Groups: Contenders
hmm

Evening

I'll also post this on the thread that you mentioned above.

As it stands, ResidueIE info makes 633 unplayable, at least for me, once you find a negative seg score. It's like trying to play a puzzle with the 'isosurface' option on. It's swamping system/CPU resources, rendering any other work you try to do, outside of FoldClub, very difficult.

I had to shut the foldit client down, just to be able to post this feedback. It's not a 'crashing' bug, it's just a 'rapaciously thirsty' code.

Angus's picture
User offline. Last seen 1 hour 43 min ago. Offline
Joined: 06/04/2008
Groups: Beta Folders
Unplayable
gitwut's picture
User offline. Last seen 46 weeks 1 day ago. Offline
Joined: 05/18/2012
Groups: Contenders
Too disruptive to continue

I'm done with this puzzle too. It crashes after I go to sleep and crashes before I get home from work. When it doesn't crash it slows everything down to a crawl.

beta_helix's picture
User offline. Last seen 11 hours 32 min ago. Offline
Joined: 05/09/2008
Groups: None
We apologize for the problems with this one.

Is anyone that is having problems NOT using a PC?

We are trying to get this resolved ASAP, if you can help answer tamirh's questions hopefully we can find the issue quickly: http://fold.it/portal/node/993596#comment-19940

Thanks again for your patience and we really apologize for this.
When we posted it in devprev there we no reports that it was unplayable or crashed this often!

Hopefully we can get this filter working properly as it should, so we can post the many exciting design puzzles that we have lined up!

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons