puzzle picture
628: Quick Freestyle Puzzle
Status: Closed

Summary

Name: 628: Quick Freestyle Puzzle
Status: Closed
Created: 09/12/2012
Points: 100
Expired: 09/18/2012 - 07:00
Difficulty: Advanced
Description: This is a repost of Puzzle 626, but using the regular scoring function. Again, we are giving you this currently unsolved protein as an extended chain. Use all your skills to fold it up as best as you can. Secondary structure predictions are in the puzzle comments.
Categories: Overall, Prediction

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2Go Science11,08183
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4Contenders10,95756
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Comments

beta_helix's picture
User offline. Last seen 6 days 19 hours ago. Offline
Joined: 05/09/2008
Groups: None
Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 7 & 68 are highly predicted to be part of a helix. However, the Valines at residues 31, 35, 43, 52, 88, 97, 101 & 120 are highly predicted to be in a sheet.

marie_s's picture
User offline. Last seen 1 year 49 weeks ago. Offline
Joined: 05/18/2008
Groups: None
see gramps' recipe
spmm's picture
User offline. Last seen 40 weeks 3 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
much smoother movement

this one is much smoother to move around and is wiggling nicely (in my opinion of course)

beta_helix's picture
User offline. Last seen 6 days 19 hours ago. Offline
Joined: 05/09/2008
Groups: None
That is great to hear, spmm!

That is exactly why we posted this puzzle and this is what we are trying to find out!

Thank you for the feedback, and thank you for your patience in playing the same puzzle back to back!

Please keep us posted...

infjamc's picture
User offline. Last seen 2 years 44 weeks ago. Offline
Joined: 02/20/2009
Groups: Contenders
Just out of curiosity...

Would it be possible to allow for loading our own solutions from 626?

beta_helix's picture
User offline. Last seen 6 days 19 hours ago. Offline
Joined: 05/09/2008
Groups: None
Sorry infjamc

That is impossible to do once a puzzle has already been posted.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons