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627: 30 Residue Symmetric Dimer of Dimers Freestyle
Status: Closed

Summary

Name: 627: 30 Residue Symmetric Dimer of Dimers Freestyle
Status: Closed
Created: 09/06/2012
Points: 100
Expired: 09/14/2012 - 19:00
Difficulty: Intermediate
Description: This is a small (30 residue) symmetric tetramer design puzzle; there will be four symmetric chains to manage. Symmetry becomes more complicated past three chains; for example, tetramers can be arranged in a ring (called "C4" symmetry) or as a dimer of dimers ("D2" or "two-by-two" symmetry). The dimer of dimers is much more common in nature, so we'll be exploring that type of symmetry first. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. This dimer of dimers has two fundamentally different interfaces: the interface between chains A and B, and the interface between dimer AB and its partner, CD. Stay tuned for higher-order symmetries; it only gets crazier from here!
Categories: Design, Overall, Symmetry

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons