puzzle picture
626: Slightly Different Freestyle Puzzle
Status: Closed

Groups

RankGroupScorePoints
1Contenders10,809100
2Void Crushers10,73587
3Anthropic Dreams10,71376
4Beta Folders10,68765
5L'Alliance Francophone10,68156
6foldeRNA10,64048
7Go Science10,62941
8Richard Dawkins Foundation10,61634
9FoldIt@Netherlands10,60629
10Gargleblasters10,60524
11Another Hour Another Point10,59520
12SETI.Germany10,42317
13Natural Abilities10,39314
14Team Hungary10,22111
15Russian team10,1719
16Brony@Home10,0667
17Friday Lab10,0436
18Geekdo9,9745
19Nerdfighters9,8304
20Freedom Folders9,7733
21GENE 4339,5622
22Crunching Family9,3002
237Monkeys9,2981
24E?????! Heureka!9,1781
25ROMANIA Team9,0191


Need this puzzle? Log in to download.  

Comments

beta_helix's picture
User offline. Last seen 1 day 2 hours ago. Offline
Joined: 05/09/2008
Groups: None
Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 7 & 68 are highly predicted to be part of a helix. However, the Valines at residues 31, 35, 43, 52, 88, 97, 101 & 120 are highly predicted to be in a sheet.

spmm's picture
User offline. Last seen 27 weeks 3 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
very stiff

this is really stiff to move even on CI= 0.3

beta_helix's picture
User offline. Last seen 1 day 2 hours ago. Offline
Joined: 05/09/2008
Groups: None
Thank you for the feedback, spmm

This is exactly what we are trying to find out by giving you a slightly different scoring function.
We will repost this as a Quick Puzzle with the regular scoring function for comparison.

Joined: 05/19/2009
Groups: Contenders
scoring == stiffness ?

In what way is a scoring function related to the stiffness of a structure ? I would think that the stiffness is not depending on a score. Can you please explain this ?

beta_helix's picture
User offline. Last seen 1 day 2 hours ago. Offline
Joined: 05/09/2008
Groups: None
I agree that it should not be dependent!

It is very strange that this puzzle would be more stiff than any other freestyle extended chain that we give you (since they are generated in the exact same way).

The only difference here (other than the amino acid sequence, obviously) is the score function.

It will be interesting to see if reposting the exact same puzzle with the traditional Foldit scoring function gets rid of this stiffness.

If not, then there might be something else going on!

Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons