Beginner 615 (TR 754) is metallorganic

Case number:845799-993444
Opened by:brow42
Opened on:Wednesday, September 5, 2012 - 07:21
Last modified:Friday, September 13, 2013 - 22:22

This puzzle, which had no fewer than 8 cysteines, many close together, is actually a metallogranic. Many players, including myself, worked very hard to get at least 3 bridges out of those 8 cysteines. The native (2lv9) has been released; it turns out there are no disulfide bridges, and 7 of the 8 cys are coordinated with either of 2 zinc atoms. These atoms aren't in the puzzle. They aren't hinted at in the CASP target info. How can we, or Rosetta@Home, or any other server, fold without these atoms present? Are they to be inferred from the void and the apparent positioning of 3-4 S atoms? Isn't it a bit disingenuous to present refinement puzzle without all the atoms? Or was the Zn truly invisible in the NMR? And if so, how did they know it was there?

(Wed, 09/05/2012 - 07:21  |  1 comment)

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Question was answered, but not really answered. :-/


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