puzzle picture
residueIE filter test
Status: Closed


Name: residueIE filter test
Status: Closed
Created: 08/22/2012
Points: 0
Expired: 09/20/2012 - 16:00
Difficulty: Intermediate
Description: We are trying this puzzle again, with a fix that was added in the most recent update to devprev. This is a repost of Puzzle 571: Tissue Regeneration Design Puzzle, this time with a new patch designed to help with scoring artifacts. PLEASE MAKE SURE YOU ARE USING THE LATEST devprev UPDATE!

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Joined: 05/03/2009
Groups: Contenders
I may be a little late to the

I may be a little late to the party.

devprev IE versus IE2, on update ( -2 now) scored 400 points more.

However, last update I caught, with the wiggle relax, scores better than -1. But the mutate core, still feels like it's missing something, and going short hphile (asn/asp) heavy. And doesnt really explore, gets to 3 or 4 chains, then gets bored. I wonder if that is the reason with low clash, that the heavy aromatics get in, and then stay in?

There's still something fundamentally funky with mutate, and the way it goes it's business. Please fix that. The easy option is fiddle with wiggle, to make it seeeem better.

All this opinion is from seeing it live, and doing it by hand. If I'm replicating scripts, then so be it, but mutate still doesnt 'Feel right'. It's not that you'll have missed a qualitative judgment from waking up from a setted script, when you wake to find gains, but it still feels like there's something wrong. And wiggle isnt the escape route.


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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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